甲硝唑联合阴道用乳杆菌活菌胶囊治疗老年性阴道炎患者的临床价值  

Clinical value of metronidazole combined with vaginallactobacillus viable capsules in the treatment ofpatients with senile vaginitis

作　　者：蔡云姣 谭国政 卢思媛 CAI Yunjiao;TAN Guozheng;LU Siyuan(Department of Obstetrics and Gynecology,Jiujiang Maternal and Child Health Hospital,Jiujiang,Jiangxi,332000,China)

机构地区：[1]九江市妇幼保健院妇产科,江西九江332000

出　　处：《当代医学》2024年第22期26-29,共4页Contemporary Medicine

摘　　要：目的探究甲硝唑联合阴道用乳杆菌活菌胶囊治疗老年性阴道炎患者的临床疗效。方法选取2021年2月至2023年2月于九江市妇幼保健院妇科接受治疗的90例老年性阴道炎患者作为研究对象,按照随机数字表法分为对照组与观察组,每组45例。对照组给予甲硝唑治疗,观察组给予甲硝唑联合阴道用乳杆菌活菌胶囊治疗。比较两组治疗前后炎症因子[白细胞介素-6(interleukin-6,IL-6)、白细胞介素-8(interleukin-8,IL-8)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)]水平、临床症状改善时间、不良反应发生率及复发率。结果治疗前,两组血清IL-6、IL-8、TNF-α水平比较差异无统计学意义;治疗后,两组血清IL-6、IL-8、TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组阴道黏膜充血、阴道瘙痒、外阴灼热不适及白带异常改善时间均短于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义;停药后1、3个月,两组复发率比较差异均无统计学意义,停药6个月后,观察组复发率低于对照组,差异有统计学意义(P<0.05)。结论甲硝唑联合阴道用乳杆菌活菌胶囊治疗老年性阴道炎能降低炎症因子水平,缩短临床症状改善时间,降低停药后远期复发率。Objective To explore the clinical efficacy of metronidazole combined with vaginal lactobacillus viable capsules in the treatment of patients with senile vaginitis.Methods A total of 90 patients with senile vaginitis who were treated in the department of Obstetrics and Gynecology in Jiujiang Maternal and Child Health Hospital from February 2021 to February 2023 were selected as the research subjects,and they were divided into the control group and the observation group according to the random number table method,with 45 cases in each group.The control group was flammatory factors (interleukin-6 [IL-6], interleukin-8 [IL-8] and tumor necrosis factor-α [TNF-α]) before and after treatment, clinical symptom improvementtime, incidence of adverse reactions and recurrence rate were compared between the two groups. Results Before treatment, there was nosignificant difference in serum levels of IL-6, IL-8 and TNF-α between the two groups;after treatment, serum levels of IL-6, IL-8 and TNF-α of thetwo groups were lower than before treatment, and the observation group was lower than the control group, the differences were statistically significant(P<0.05). The improvement time of vaginal mucosal congestion, vaginal itching, vulvar burning discomfort, and abnormal vaginal discharge inthe observation group were shorter than those in the control group, the differences were statistically significant (P<0.05). There was no significantdifference in the incidence of adverse reactions between the two groups. After 1, 3 months of drug withdrawal, there were no significance differencesin the recurrence rate between the two groups;after 6 months of drug withdrawal, the recurrence rate in the observation group was lower than that inthe control group, the difference was statistically significant (P<0.05). Conclusion Metronidazole combined with vaginal lactobacillus viable capsulesin the treatment of patients with senile vaginitis can reduce the levels of inflammatory factors, shorten the time for clinical symptom recovery,and reduce

关 键 词：老年性阴道炎 甲硝唑 阴道用乳杆菌活菌胶囊 炎症因子 复发率 

分 类 号：R71[医药卫生—妇产科学]