右美托咪定联合丙泊酚在乳腺外科良性包块切除术中的应用  

Application of dexmedetomidine combined with propofol in benign mass resection in breast surgery

作　　者：万平波 敖怡 杨杰文 WAN Pingbo;AO Yi;YANG Jiewen(Department of Anesthesiology,Xinyu Maternal and Child Health Hospital,Xinyu,Jiangxi,338025,China)

机构地区：[1]新余市妇幼保健院麻醉科,江西新余338025

出　　处：《当代医学》2024年第22期38-42,共5页Contemporary Medicine

基　　金：新余市科技计划项目(20223090971)。

摘　　要：目的探讨右美托咪定联合丙泊酚在乳腺外科良性包块切除术中的应用效果。方法选取2022年1月至2024年1月于新余市妇幼保健院行乳腺包块切除术的60例患者作为研究对象,采用随机数字表法分为观察组与对照组,每组30例。对照组给予丙泊酚麻醉,观察组给予右美托咪定联合丙泊酚麻醉。比较两组临床指标、生命体征[平均动脉压(mean arterial pressure,MAP)、心率(heart rate,HR)、呼吸频率(respiratory rate,RR)、经皮动脉血氧饱和度(percutaneous arterial oxygen saturation,SpO2)]、视觉模拟评分法(visual analogue scale,VAS)评分、Ramsay镇静评分、抑郁自评量表(self-rating depression scale,SDS)评分、焦虑自评量表(self-rating anxiety scale,SAS)评分、不良反应发生情况、麻醉满意度。结果观察组定向力恢复时间、呼吸恢复时间、抬下颌时间、术后苏醒时间均短于对照组,丙泊酚用量少于对照组,差异有统计学意义(P<0.05)。T1~T3时,观察组MAP小于对照组,RR、HR均慢于对照组,SpO2均高于对照组,差异有统计学意义(P<0.05)。术后1 h,观察组VAS评分低于对照组,Ramsay镇静评分高于对照组,差异有统计学意义(P<0.05)。术后1 h,观察组SDS、SAS评分均低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为3.33%,低于对照组的20.00%,但组间比较差异无统计学意义。观察组麻醉总满意度为96.67%,高于对照组的66.67%,差异有统计学意义(P<0.05)。结论右美托咪定联合丙泊酚麻醉应用于乳腺外科良性包块切除术中麻醉效果显著,能促进患者更快苏醒,增强镇痛、镇静效果,且安全性较高,值得临床推广应用。Objective To explore the application effect of dexmedetomidine combined with propofol in benign mass resection in breast surgery.Methods 60 patients who underwent breast mass resection surgery in Xinyu Maternal and Child Health Hospital from January 2022 to January 2024 were selected as the research subjects,and they were divided into the observation group and the control group according to the random number table method,with 30 cases in each group.The control group was anesthetized with propofol,while the observation group was anesthetized with dexmedetomidine combined with propofol.The clinical indicators,vital signs(mean arterial pressure[MAP],heart rate[HR],respiratory rate[RR],percutaneous arterial oxygen saturation[SpO2]),visual analogue scale(VAS)score,Ramsay sedation score,self-rating depression scale(SDS)score,self-rating anxiety scale(SAS)score,occurrence of adverse reactions,and satisfaction with anesthesia were compared between the two groups.Results The recovery time of orientation,respiratory recovery time,mandibular lifting time,and postoperative recovery time in the observation group were shorter than those in the control group,propofol dosage was less than that in the control group,and the differences were statistically significant(P<0.05).At T1-T3,the MAP in the observation group were smaller than that in the control group,RR,HR were slower than those in the control group,and SpO2 was higher than that in the control group,and the differences were statistically significant(P<0.05).At 1 h after operation,VAS score in the observation group was lower than in the control group,Ramsay sedation score was higher than that in the control group,the differences were statistically significant(P<0.05).At 1 h after operation,SDS and SAS scores in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.33%,which was lower than 20.00%in the control group,but there was no significan

关 键 词：右美托咪定 丙泊酚 乳腺外科 包块切除术 

分 类 号：R47[医药卫生—护理学]