全杜仲胶囊辅助治疗对高血压肾病患者血压变异性和肾动脉血流动力学及预后的影响  

Effect of Quanduzhong capsule adjuvant therapy on blood pres-sure variability and renal artery hemodynamics and prognosis in patients with hypertensive nephropathy

作　　者：张嘉骐 单皆 骆丰丰 ZHANG Jiaqi;SHAN Jie;LUO Fengfeng(Department of Nephrology,First People's Hospital of Fuzhou,Fuzhou,Jiangxi,344000,China)

机构地区：[1]抚州市第一人民医院肾内科,江西抚州344000

出　　处：《当代医学》2024年第22期55-58,共4页Contemporary Medicine

摘　　要：目的探讨全杜仲胶囊辅助治疗对高血压肾病(hypertensive nephropathy,HN)患者血压变异性(blood pres-sure variability,BPV)、肾动脉血流动力学及预后的影响。方法选取2020年6月至2022年6月抚州市第一人民医院收治的100例HN患者作为研究对象,按照单双号法随机分为对照组与观察组,每组50例。对照组给予盐酸地尔硫卓片口服治疗,观察组在对照组基础上给予全杜仲胶囊,比较两组BPV指标[24 h收缩压(shrink blood pressure,SBP)、24 h舒张压(diastole blood pressure,DBP),24 h收缩压变异(diastole blood pressure variation,SBPV)、24 h舒张压变异(diastole blood pressure variation,DBPV)]、血流动力学指标[肾主动脉、段动脉收缩期峰值血流速度(peak systolic velocity,PSV)、舒张末期血流速度(end diastolic velocity,EDV)]、肾功能指标[尿蛋白(protein,Pro)、尿β2-微球蛋白(urineβ2-micro globulin,β2-MG)、血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,SCr)]水平及靶器官损伤情况。结果治疗后,两组24 h SBP、24 h DBP、24 h SBPV、24 h DBPV均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组肾主动脉PSV、肾主动脉EDV、段动脉EDV及观察组段动脉PSV均慢于治疗前,且观察组肾主动脉、段动脉PSV与EDV均慢于对照组,差异有统计学意义(P<0.05)。治疗后,对照组β2-MG水平低于治疗前,观察组SCr、BUN、Pro、β2-MG水平均低于治疗前及对照组,差异有统计学意义(P<0.05)。两组靶器官损伤发生率比较差异无统计学意义。结论全杜仲胶囊联合盐酸地尔硫卓片治疗HN能有效调节患者BPV,改善肾动脉血流动力学及肾功能,靶器官损伤发生率无明显变化,预后较好。Objective To investigate the effect of Quanduzhong capsule adjuvant therapy on blood pres-sure variability(BPV),renal artery hemodynamics and prognosis in patients with hypertensive nephropathy(HN).Methods 100 patients with HN admitted to the First People's Hospital of Fuzhou from June 2020 to June 2022 were selected as the research subjects,they were randomly divided into the control group and the observation group according to the odd and even number method,with 50 cases in each group.The control group was treated with diltiazem hydrochloride tablets orally,and the observation group was given Quanduzhong capsule on the basis of the control group,The levels of BPV indexes(24 h systolic blood pressure[SBP],24 h diastolic blood pressure[DBP],24 h systolic blood pressure variation[SBPV],24 h diastolic blood pressure variation[DBPV]),hemodynamic indexes(peak systolic velocity[PSV],end diastolic velocity[EDV]of renal aorta and segmental artery),renal function indexes(protein[Pro],urineβ2-microglobulin[β2-MG],blood urea nitrogen[BUN],serum creatinine[SCr])and target organ damage were compared between the two groups.Results After treatment,24 h SBP,24 h DBP,24 h SBPV and 24 h DBPV of the two groups were lower than those before treatment,and the observation group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,PSV of renal aorta,EDV of renal aorta,EDV of segmental artery of the two groups and PSV of segmental artery in the observation group were slower than those before treatment,and PSV and EDV of renal aorta and segmental artery in the observation group were slower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the level ofβ2-MG in the control group was lower than that before treatment,and the levels of SCr,BUN,Pro andβ2-MG in the observation group were lower than those before treatment and the control group,the differences were statistically significant(P<0.05).There was no significant difference in th

关 键 词：全杜仲胶囊 地尔硫卓 高血压肾病 血压变异性 

分 类 号：R54[医药卫生—心血管疾病]