3~6岁慢性咳嗽患儿粉尘螨变应原皮肤点刺试验的影响因素及与血清IgE水平的相关性分析  

Analysis of factors influencing the skin prick test fordust mite allergens and its correlation with serum IgElevels in children aged 3 to 6 years with chronic coughs

作　　者：张艳清 袁航 曾凯丹 胡冰 ZHANG Yanqing;YUAN Hang;ZENG Kaidan;HU Bing(Department of Pediatrics,Yichun People's Hospital,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春市人民医院儿科,江西宜春336000

出　　处：《当代医学》2024年第22期146-149,共4页Contemporary Medicine

摘　　要：目的分析3~6岁慢性咳嗽患儿粉尘螨变应原皮肤点刺试验(skin-prick test,SPT)的影响因素及与IgE水平的相关性。方法回顾性分析2022年1月至2023年1月宜春市人民医院收治的100例3~6岁慢性咳嗽患儿的临床资料,所有患儿均接受粉尘螨SPT检测与血清IgE检查。统计患儿SPT结果,比较血清IgE与SPT阳性率,并采用Spearman相关性分析患儿粉尘螨SPT阳性强度与血清IgE阳性强度的关系,依据SPT结果将患儿分为阳性组与阴性组,采用单因素及多因素Logistic回归分析SPT检测结果的影响因素。结果100例患儿中,SPT阴性35例(35.00%),阳性患儿65例(65.00%),其中,(+)25例(30.00%)、(++)20例(20.00%)、(+++)14例(14.00%)、(++++)6例(6.00%)。患儿血清SPT阳性率为65.00%,高于IgE的49.00%,差异有统计学意义(P<0.05)。Spearman相关性分析显示,患儿粉尘螨SPT阳性强度与血清IgE阳性强度呈正相关(r>0,P<0.05)。两组居住地、居住环境潮湿、居住环境灰尘暴露、家中饲养动物、室内养花、母乳喂养及食用海鲜情况比较差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,居住地城区、居住环境潮湿、居住环境灰尘暴露、家中饲养动物、室内养花及食用海鲜均为粉尘螨SPT检测结果阳性的独立危险因素(P<0.05),母乳喂养是粉尘螨SPT检测结果阳性的保护因素(P<0.05)。结论3~6岁慢性咳嗽度患儿粉尘螨的SPT结果与血清IgE水平具有相关性,居住地城区、居住环境潮湿、居住环境灰尘暴露、家中饲养动物、室内养花及食用海鲜均为粉尘螨SPT检测结果阳性的独立危险因素,应采取不同的干预措施进行预防。Objective To analyze the factors influencing the skin-prick test(SPT)for dust mite allergens and its correlation with IgE levels in children aged 3 to 6 years with chronic cough.Methods The clinical data of 100 children with chronic cough aged 3-6 years admitted to Yichun People's Hospital from January 2022 to January 2023 were retrospectively analyzed,and all of them received dust mite SPT test with serum IgE examination.The SPT results of the children were counted,and the positive rates of serum IgE and SPT were compared,and Spearman correlation was used to analyze the relationship between the intensity of SPT positivity of dust mites and the intensity of serum IgE positivity of the children,based on the SPT results,the children were divided into the positive group and the negative group,and the influencing factors affecting the SPT results were analyzed by using unifactorial and multifactorial Logistic regression.Results Out of 100 children,35 cases(35.00%)were SPT negative and 65 cases(65.00%)were positive,of which 25 cases(30.00%)were(+),20 cases(20.00%)were(++),14 cases(14.00%)were(++++)and 6 cases(6.00%)were(++++).The serum SPT positivity rate of the children was 65.00%,which was higher than that of 49.00%for IgE,and the difference was statistically significant(P<0.05).Spearman's correlation analysis showed that the intensity of SPT positivity for dust mites in the children was positively correlated with the intensity of IgE positivity in the serum(r>0,P<0.05).There were statistically significant differences in places of residence,dampness of the living environment,dust exposure of living environment,raising animals at home,indoor flower raising,breastfeeding and seafood consumption between the two groups(P<0.05).Multivariate Logistic regression analysis showed that residence,urban area of residence,dampness of the living environment,exposure to dust in the living environment,keeping animals at home,indoor flowers and consumption of seafood were the independent risk factors for a positive result of dust mi

关 键 词：慢性咳嗽 粉尘螨 皮肤点刺试验 影响因素 

分 类 号：R72[医药卫生—儿科]