基于药代动力学的临床常见药物急性中毒血液净化治疗共识  

Consensus for Blood Purification Therapy Based on Pharmacokinetics in Acute Poisoning from Commonly Used Clinical Drugs

作　　者：《基于药代动力学的临床常见药物急性中毒血液净化治疗共识》专家组 潘龙飞[7] 马青变[3] 朱华栋[4] 张国强[5] 马岳峰[6] 裴红红[2] 孙宝妮 张莉[7] Expert Group on the Consensus for Blood Purification Therapy Based on Pharmacokinetics in Acute Poisoning from Commonly Used Clinical Drugs;PAN Longfei;MA Qingbian;ZHU Huadong;ZHANG Guoqiang;MA Yuefeng;PEI Honghong

机构地区：[1]不详 [2]西安交通大学第二附属医院 [3]北京大学第三医院 [4]中国医学科学院北京协和医院 [5]中日友好医院 [6]浙江大学医学院附属第二医院 [7]西安交通大学第二附属医院急诊科

出　　处：《中国全科医学》2025年第9期1033-1043,共11页Chinese General Practice

摘　　要：近年来,药物导致的急性中毒逐年增多,但多数药物中毒缺乏特效解毒剂。血液净化治疗在药物急性中毒治疗方面具有重要作用,但目前国内关于其在临床常见药物急性中毒方面的应用尚无统一推荐意见。本专家共识以药代动力学为核心,对血液净化治疗在临床常见药物急性中毒治疗中的应用策略进行归纳、总结,旨在增进临床医生对药代动力学特征及相应血液净化治疗模式的理解,从而使其在诊治药物急性中毒患者时可以基于导致中毒药物的药代动力学特征选择合理的血液净化治疗模式并制订恰当的血液净化治疗方案,最终提高临床常见药物急性中毒患者的救治效果。The incidence of acute poisoning caused by commonly used clinical drugs has been increasing annually,yet specific antidotes are lacking for most drug poisonings.Blood purification plays a crucial role in the treatment of acute poisoning.However,there are currently no unified recommendations in China regarding its application in cases of acute poisoning from commonly used clinical drugs.This consensus centers on pharmacokinetics,summarizing and outlining the strategies for applying blood purification in the treatment of acute poisoning caused by these drugs.Its aim is to assist clinicians in improving their understanding of pharmacokinetic parameters and the corresponding blood purification methods,so that they can select the appropriate blood purification technique and develop suitable treatment plans based on the pharmacokinetic characteristics of the drug involved.Ultimately,this seeks to improve outcomes in treating patients with acute poisoning from commonly used clinical drugs.

关 键 词：中毒 药物过量 药代动力学 连续性肾替代疗法 急性中毒 药物中毒 血液净化 

分 类 号：R595.4[医药卫生—内科学]