外泌体微小RNA参与糖尿病足溃疡修复的研究进展  

Research Progress of Exosome miRNA Involved in the Repair of Diabetic Foot Ulcer

作　　者：岑妮秒 韦云师 黄丽娜 吴标良[1] CEN Nimiao;WEI Yunshi;HUANG Lina;WU Biaoliang(Department of Endocrinology,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,China;Graduate School of Youjiang Medical University for Nationalities,Baise 533000,China)

机构地区：[1]右江民族医学院附属医院内分泌科,广西壮族自治区百色市533000 [2]右江民族医学院研究生学院,广西壮族自治区百色市533000

出　　处：《中国全科医学》2025年第9期1156-1160,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(81960875);广西自然科学基金资助项目(2023GXNSFDA026008);广西医疗卫生适宜技术开发与推广应用项目(S2022134)。

摘　　要：糖尿病足溃疡(DFU)通常伴有不同程度的周围神经病变和血管病变,是一种难愈合创面,其愈合延迟过程主要是有新血管再生障碍、持续的创面炎症反应、创面再上皮化障碍及成纤维细胞增殖异常。外泌体微小RNA(miRNA)作为细胞间通讯的重要介质,参与多种生物学过程,可调控影响DFU愈合的多种靶基因转录翻译。本文旨在简要综述外泌体miRNA对新血管再生、炎症反应、创面再上皮化功能以及成纤维细胞增殖功能在DFU修复中的调控作用,以期为DFU的治疗提供新思路。Diabetic foot ulcer(DFU)is usually accompanied by varying degrees of peripheral neuropathy and vasculopathy.It is a difficult-to-heal wound.The delayed healing process is mainly due to new blood vessel regeneration disorder,persistent wound inflammation,wound re-epithelialization disorder and abnormal fibroblast proliferation.Exosomal miRNA,as an important medium for intercellular communication,is involved in a variety of biological processes and can regulate the transcription and translation of various target genes affecting DFU healing.This paper aims to briefly review the role of exosomal miRNAs in the regulation of neointimal regeneration,inflammatory response,wound re-epithelialization function,and fibroblast proliferation function in the repair of DFU,to provide new ideas for the treatment of DFU.

关 键 词：糖尿病足溃疡 外泌体 微小核糖核酸 综述 

分 类 号：R587.42[医药卫生—内分泌]