羟苯磺酸钙联合沙格列汀对早期糖尿病肾病患者肾功能、血管内皮活性物质、足细胞损伤因子及炎症因子的影响  

Effect of calcium hydroxybenzenesulfonate combined with saxagliptin on serum renal function,vascular endothelial reactive substances,podocyte injury factor and inflammatory factor in patients with early diabetic nephropathy

作　　者：孙艳红 陈丽 赵文化 SUN Yan-hong;CHEN Li;ZHAO Wen-hua(Department of Endocrinology,Changzhi People's Hospital,Changzhi Shanxi 046000,China)

机构地区：[1]长治市人民医院内分泌科,山西长治046000

出　　处：《临床和实验医学杂志》2024年第23期2494-2498,共5页Journal of Clinical and Experimental Medicine

基　　金：山西省卫生健康委员会科研课题(编号:2018080)。

摘　　要：目的观察羟苯磺酸钙联合沙格列汀对早期糖尿病肾病(DN)患者肾功能、血管内皮活性物质、足细胞损伤因子及炎症因子的影响。方法前瞻性选取2021年4月至2022年9月就诊于长治市人民医院内分泌科的108例早期DN患者为对象,按照随机数字表法将其分为两组,每组各54例。对照组给予羟苯磺酸钙治疗,观察组给予羟苯磺酸钙+沙格列汀治疗。检测治疗前、治疗4周后两组肾功能[血肌酐、胱抑素-C、24 h尿蛋白(24 hUpro)、β2-微球蛋白(β2-MG)、尿素氮]、血管内皮活性物质[血管内皮生长因子(VEGF)、内皮素-1、血栓素B2(TXB2)、一氧化氮]、足细胞损伤指标(Podocin、Nephrin)及炎症因子[单核细胞趋化因子-1(MCP-1)、趋化因子配体9(CXCL9)、白细胞介素-18(IL-18)]差异,统计两组疗效。结果治疗4周后,两组血肌酐、尿素氮、胱抑素-C、24 hUpro、β2-MG均较治疗前降低,且观察组的血肌酐、尿素氮、胱抑素-C、24 hUpro、β2-MG分别为(90.24±5.82)μmol/L、(5.07±0.76)mmol/L、(1.24±0.33)mg/L、(67.78±12.04)mg、(1.21±0.40)mg/L,均低于对照组[(94.25±6.23)μmol/L、(5.45±0.83)mmol/L、(1.77±0.36)mg/L、(76.23±14.47)mg、(1.82±0.44)mg/L],差异均有统计学意义(P<0.05)。治疗4周后,两组内皮素-1、TXB2、VEGF均较治疗前降低,一氧化氮治疗后较治疗前升高,且观察组的一氧化氮为(82.11±11.56)μmol/L,高于对照组[(74.25±9.86)μmol/L],内皮素-1、TXB2、VEGF水平分别为(30.79±6.77)μg/L、(87.96±11.07)ng/L、(127.14±28.51)ng/mL,均低于对照组[(41.56±8.03)μg/L、(115.45±13.86)ng/L、(142.26±32.65)ng/mL],差异均有统计学意义(P<0.05)。治疗4周后,两组Podocin、Nephrin均较治疗前降低,且观察组的Podocin、Nephrin水平分别为(0.74±0.19)、(1.31±0.74)ng/mL,均低于对照组[(1.23±0.21)、(1.92±0.96)ng/mL],差异均有统计学意义(P<0.05)。治疗4周后,两组MCP-1、IL-18、CXCL9水平均较治疗前降低,且观察组的MCP-1、IL-18、Objective To observe the effects of calcium hydroxybenzenesulfonate combined with saxagliptin on serum renal function,vascular endothelial reactive substances,podocyte damage factor and inflammatory factor in patients with early diabetic nephropathy(DN).Methods A total of 108 patients with early DN who were admitted to the Department of Endocrinology,Changzhi People's Hospital from April 2021 to September 2022 were prospectively selected as subjects.They were divided into two groups according to the random number table method,with 54 cases in each group.The control group was given calcium hydroxybenzenesulphonate treatment,and the observation group was given calcium hydroxybenzenesulphonate+saxagliptin treatment.Renal function[blood creatinine,cystatin-C,24 hUpro,β2-microglobulin(β2-MG),urea nitrogen],vascular endothelial reactive substances[vascular endothelial growth factor(VEGF),endothelin-1,thromboxane B2(TXB2),nitric oxide],indicators of podocyte damage(Podocin,Nephrin)and inflammatory factors[monocyte chemokine-1(MCP-1),chemokine 9(CXCL9),interleukin-18(IL-18)]differences,and the efficacy of the two groups were counted.Results After 4 weeks of treatment,the serum creatinine,urea nitrogen,cystatin-C,24 hUpro andβ2-MG in the two groups were lower than those before treatment,and the serum creatinine,urea nitrogen,cystatin-C,24 hUpro andβ2-MG in the observation group were(90.24±5.82)μmol/L,(5.07±0.76)mmol/L,(1.24±0.33)mg/L,(67.78±12.04)mg and(1.21±0.40)mg/L,respectively,which were lower than those in the control group[(94.25±6.23)μmol/L,(5.45±0.83)mmol/L,(1.77±0.36)mg/L,(76.23±14.47)mg,(1.82±0.44)mg/L],the differences were statistically significant(P<0.05).The nitric oxide in the observation group was(82.11±11.56)μmol/L,which was higher than that in the control group[(74.25±9.86)μmol/L],the levels of endothelin-1,TXB2 and VEGF were(30.79±6.77)μg/L,(87.96±11.07)ng/L and(127.14±28.51)ng/mL,respectively,which were lower than those in the control group[(41.56±8.03)μg/L,(115.45±13.86)ng/L�

关 键 词：羟苯磺酸钙 肾功能 血管内皮活性物质 糖尿病肾病 足细胞损伤 沙格列汀 

分 类 号：R54[医药卫生—心血管疾病]