微针联合一氧化氮源复合物溶液治疗女性型脱发疗效与安全性研究  

Efficacy and safety of generating nitric oxide complex solution combined with microneedles on female pattern hair loss patients

作　　者：杨阳[1] 常琳琳 李鑫[1] 张迪 禚风麟[2] YANG Yang;CHANG Lin-lin;LI Xin(Department of Dermatology,Beiing Puren Hospital,Beijing 100062,China;Department of Dermatology,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]北京市普仁医院皮肤科,北京100062 [2]首都医科大学附属北京友谊医院皮肤科,北京100050

出　　处：《临床和实验医学杂志》2024年第23期2565-2569,共5页Journal of Clinical and Experimental Medicine

基　　金：国家自然科学基金资助项目(编号:82273555)。

摘　　要：目的观察微针联合一氧化氮源复合物溶液治疗女性型脱发(FPHL)的临床疗效与安全性。方法选取2023年11月至2024年2月首都医科大学附属北京友谊医院皮肤科门诊招募的SinclairⅡ、Ⅲ级月经规律的FPHL患者共60例进行前瞻性研究。按照随机数字表法将患者分为实验组和对照组,每组各30例。实验组给予微针联合一氧化氮源复合物溶液治疗,一氧化氮源复合物溶液1次/周,共5次,其后1次/2周,共5次,共14周;对照组给予米诺地尔酊治疗,外涂5%米诺地尔酊1 mL,1次/d,共14周。比较治疗16周时两组组内和组间毛发生长情况(毛发镜下毛发密度、毛发直径),医师评价(Sinclair脱发分级变化、7级评分法),患者评价(生活质量调查问卷、主观满意度)及不良反应发生情况。结果治疗16周时,两组毛发密度、毛发直径均较治疗前有明显改善,差异均有统计学意义(P<0.05);治疗16周时,两组间毛发密度、毛发直径的平均值比较,差异均无统计学意义(P>0.05)。治疗16周时,实验组有效率为50.0%,对照组有效率为43.3%,差异无统计学意义(P>0.05)。治疗16周时,两组WAA-QOL评分均明显高于治疗前,实验组WAA-QOL评分为72(68,80)分,高于对照组[57(50,67)分],差异均有统计学意义(P<0.05)。实验组总体满意率为86.7%,显著高于对照组(76.7%),差异有统计学意义(P<0.05)。实验组不良反应发生率为13.3%,显著低于对照组(73.3%),差异有统计学意义(P<0.05)。结论微针联合一氧化氮源复合物溶液治疗FPHL与外涂米诺地尔溶液疗效无差异,可有效促进毛发生长,且微针联合一氧化氮源复合物溶液较外涂米诺地尔溶液不良反应少,安全性更好。Objective This study aims to compare the efficacy and safety of generating nitric oxide complex solution combined with microneedles on female pattern hair loss(FPHL)patients.Methods A total of 60 FPHL patients with SinclairⅡandⅢmenstrual regularity recruited from the dermatology clinic of Beijing Friendship Hospital,Capital Medical University from November 2023 to February 2024 were prospectively studied.According to the random number table method,the patients were divided into the experimental group and the control group,with 30 cases in each group.The experimental group was treated with microneedle combined with nitric oxide source complex solution,nitric oxide source complex solution 1 time/week,a total of 5 times,followed by 1 time/2 weeks,a total of 5 times,a total of 14 weeks;the control group was treated with minoxidil tincture,1 mL of 5%minoxidil tincture was applied once a day for 14 weeks.Hair growth(hair density and hair shaft diameter under dermatoscope)in intra-group and intergroup,physician evaluation(Sinclair's scores and 7-point global-assessment scale),patient evaluation(the women's androgenetic alopecia quality of life questionnaire and patients'satisfaction)and the adverse effects were compared at 16 weeks of treatment.Results At 16 weeks of treatment,the hair density and hair diameter of the two groups were significantly improved compared with those before treatment,and the differences were statistically significant(P<0.05).At 16 weeks of treatment,there was no statistically significant difference in the mean values of hair density and hair diameter between the two groups(P>0.05).At 16 weeks of treatment,the effective rate was 50.0%in the experimental group and 43.3%in the control group,and the difference was not statistically significant(P>0.05).At 16 weeks of treatment,the WAA-QOL scores of the two groups were significantly higher than those before treatment.The WAA-QOL score of the experimental group was 72(68,80)points,which was higher than that of the control group[57(50,67)points],an

关 键 词：女性型脱发 米诺地尔酊 一氧化氮源复合物溶液 疗效 安全性 

分 类 号：R47[医药卫生—护理学]