N-金刚烷咪唑酰胺的合成工艺研究  

Study on Synthesis Technology of N-amantadine Imidazolamide

作　　者：王诗灿 文颖 王语 唐泽言 李红标 Wang Shican;Wen Ying;Wang Yu;Tang Zeyan;Li Hongbiao(College of Chemistry and Chemical Engineering,Changjiang Normal University,Chongqing,408100)

机构地区：[1]长江师范学院化学化工学院,重庆408100

出　　处：《当代化工研究》2024年第23期149-151,共3页Modern Chemical Research

基　　金：重庆市大学生创新创业训练项目“新型超强酸催化剂的制备及其在PET酯化反应中的应用研究”(项目编号:S202410647036)。

摘　　要：咪唑类化合物因其良好的生物学活性,在医药和有机合成中具有广泛的应用。金刚烷胺因其特殊的稳定性和生物活性,也被应用于一些药物分子的合成中。在综合调研已有文献的基础上,发展了简便、可行的方法,合成了N-金刚烷咪唑酰胺化合物,并对关键步骤进行了系统优化,旨在发展完整、高效的方法实现N-金刚烷基咪唑酰胺的合成,并对其工业化提供指导,具有一定的现实和理论意义。Imidazole compounds have been widely used in medicine and organic synthesis because of their good biological activities.Amantadine is also used in the synthesis of some drug molecules because of its special stability and biological activities.Based on a comprehensive review of reported literature,a simple and feasible method for the synthesis of N-amantadine imidazolamide was developed,the key steps were also optimized systematically,aiming to develop a complete and efficient method for the synthesis of N-amantadine imidazolamide,and providing guidance for its industrialization,which has some practical and theoretical significance.

关 键 词：合成工艺 N-金刚烷咪唑酰胺 咪唑衍生物 

分 类 号：O657[理学—分析化学]