CaO_(2)的合成及抗菌性能研究  

Synthesis and Antimicrobial Properties of CaO_(2)

作　　者：欧阳梓荻 邓佳怡 赵雯婷 卢求钧 Ouyang Zidi;Deng Jiayi;Zhao Wenting;Lu Qiujun(College of Biological and Chemical Engineering,Changsha University,Hu'nan,410022)

机构地区：[1]长沙学院生物与化学工程学院,湖南410022

出　　处：《当代化工研究》2024年第23期158-160,共3页Modern Chemical Research

基　　金：湖南省教育厅科学研究项目优秀青年项目“基于碳纳米材料的碳青霉烯类耐药菌快速检测研究”(项目编号:21B0764);国家自然科学基金青年科学基金项目“基于适配体和非酶信号放大的嗜水气单胞菌快速检测技术研究”(项目编号:32303040);国家级大学生创新训练计划项目“pH响应型自供H2O_(2)纳米材料的合成及其抗菌性能研究”(项目编号:S202411077008)。

摘　　要：基于活性氧(Reactive Oxygen Species,ROS)的抗菌功能性纳米材料凭借其广谱杀菌能力、不产生耐药性等优势,在抗菌领域展现出广阔的应用前景。以氢氧化钙、过氧化氢等为原料,成功制备出CaO_(2)抗菌材料,并对其进行了相关表征。利用其在酸性条件下自分解释放过氧化氢从而释放活性氧来实现对细菌的杀灭作用。以大肠杆菌和金黄色葡萄球菌为代表对CaO_(2)的抗菌性能进行了分析,结果表明CaO_(2)对金黄色葡萄球菌和大肠杆菌表现出较强的广谱抗菌性能。杀菌率随CaO_(2)浓度的提高而增加,当CaO_(2)的浓度≥1.6mg/mL时对金黄色葡萄球菌的抗菌率可以达到100%,当CaO_(2)的浓度≥1.8mg/mL时,对大肠杆菌的抗菌率可以达到100%,显示出良好的抗菌应用潜力。Antimicrobial functional nanomaterials based on reactive oxygen species(ROS)have shown broad application prospects in the field of antimicrobial due to their broad-spectrum bactericidal ability and non-drug resistance.Calcium peroxide particles(CaO_(2))were successfully prepared using calcium hydroxide and hydrogen peroxide as raw materials,and its relevant characterization were carried out.Under the slightly acidic conditions of bacterial infection,CaO_(2)are able to self-decompose and release hydrogen peroxide,generating large amounts of ROS to killing the bacteria.The in vitro antimicrobial performance of CaO_(2)were investigated using Escherichia coli and Staphylococcus aureus as representatives.The results showed that CaO_(2)exhibited strong antimicrobial performance against S.aureus and E.coli.The bactericidal rate increased with the increase of CaO_(2)concentration,and the antimicrobial rate against S.aureus could reach 100%when the CaO_(2)concentration was greater than or equal to 1.6 mg/mL,and the antimicrobial rate against E.coli exceeded 100%when the CaO_(2)concentration was greater than or equal to 1.8 mg/mL.

关 键 词：过氧化钙 抗菌材料 活性氧 

分 类 号：R44[医药卫生—诊断学]