超声心动图参数及血清hs-CRP水平与慢性心力衰竭患者近期预后的相关性分析及临床价值  

Correlation analysis and clinical value of echocardiographic parameters and serum hs-CRP level with short-term prognosis in patients with chronic heart failure

作　　者：王凤 靳潇曼 杨艳芳[3] WANG Feng;JIN Xiaoman;YANG Yanfang(Color Ultrasound Room,The Third People's Hospital of Jiyuan City,Jiyuan 459000,China;Department of Clinical Laboratory,Jiyuan People's Hospital,Jiyuan 459000,China;Department of Critical Care Medicine,Jiyuan People's Hospital,Jiyuan 459000,China)

机构地区：[1]济源市第三人民医院彩超室,河南济源459000 [2]济源市人民医院检验科,河南济源459000 [3]济源市人民医院重症医学科,河南济源459000

出　　处：《黑龙江医药科学》2025年第1期27-30,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关联合共建项目,编号:LHGJ20221070。

摘　　要：目的:分析超声心动图参数左心室舒张末期内径(left ventricular end-diastolic diameter, LVEDD)、左室舒张末期容积(left ventricular end-diastolic volume, LVEDV)、左心室收缩末期内径(left ventricular end-systolic diameter, LVESD)、左心室射血分数(left ventricular ejection fraction, LVEF)及血清超敏C-反应蛋白(high-sensitivity C-reactive protein, hs-CRP)水平与慢性心力衰竭患者近期预后的相关性及临床价值。方法:选取2021年7月至2023年9月济源市第三人民医院收治的115例慢性心力衰竭患者为研究组及同期115例健康体检者为对照组;另根据患者近期不同预后分为预后良好及预后不良患者。对比两组及不同预后患者入院时超声心动图参数及血清hs-CRP水平,偏回归分析超声心动图参数及血清hs-CRP与慢性心力衰竭患者预后的关联性,并分析其对慢性心力衰竭患者预后不良的预测价值。结果:研究组入院时超声心动图参数LVEF、LVEDV[(46.28±5.41)%、(46.36±3.19)mm]均低于对照组[(67.94±6.62)%、(82.49±4.52)mm]、研究组参数LVEDD、LVESD及血清hs-CRP[(55.67±4.33)mm、(46.04±3.77)mm、(10.57±2.11)mg/L]表达均高于对照组[(47.39±5.3)mm、(37.84±2.49)mm、(5.11±1.24)mg/L],差异有统计学意义(P<0.05);预后不良患者参数LVEF、LVEDV[(40.16±3.41)%、(44.16±2.170)mm]均低于预后良好患者[(49.67±4.16)%、(50.33±2.55)mm]、参数LVEDD、LVESD及血清hsCRP表达[(61.51±2.24)mm、(50.16±3.49)mm、(19.84±2.37)mg/L]均高于预后良好患者[(52.44±2.77)mm、(43.76±3.31)mm、(5.44±3.34)mg/L],差异有统计学意义(P<0.05);入院时超声心动图参数LVEDD、LVESD及血清hsCRP水平为慢性心力衰竭预后不良的危险因素、参数LVEF、LVEDV为患者预后不良的保护因素,差异有统计学意义(P<0.05);参数各指标及血清hs-CRP水平单独及联合预测患者预后不良的曲线下面积(AUC)分别为0.675、0.661、0.673、0.629、0.691、0.793,均高于各指标单独诊断。�Objective:To analyze the correlation and clinical value of echocardiographic parameters[left ventricular end-diastolic diameter(LVEDD),left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic diameter(LVESD),left ventricular ejection fraction(LVEF)]and serum high-sensitivity C-reactive protein(hs-CRP)levels with the short-term prognosis of patients with chronic heart failure.Methods:115 patients with chronic heart failure in the Third People's Hospital of Jiyuan City from July 2021 to September 2023 were enrolled as the study group,and 115 healthy individuals during the same period were served as the control group.Patients in the study group were further divided into good prognosis and poor prognosis subgroups based on their recent prognosis.The echocardiographic parameters and serum hs-CRP levels upon admission were compared between the two groups and between patients with different prognoses.Partial regression analysis was performed to assess the association between echocardiographic parameters,serum hs-CRP levels and the prognosis of chronic heart failure.Additionally,the predictive value of these factors for poor prognosis in chronic heart failure patients was analyzed.Results:The study group exhibited lower LVEF and LVEDV echocardiographic parameters[(46.28±5.41)%,(46.36±3.19)mm]compared to the control group[(67.94±6.62)%,(82.49±4.52)mm],while LVEDD,LVESD,and serum hs-CRP parameters[(55.67±4.33)mm,(46.04±3.77)mm,(10.57±2.11)mg/L]were higher,with statistically significant differences(P<0.05).Patients with poor prognosis had lower LVEF and LVEDV[(40.16±3.41)%,(44.16±2.17)mm]and higher LVEDD,LVESD and serum hs-CRP parameters[(61.51±2.24)mm,(50.16±3.49)mm,(19.84±2.37)mg/L]compared to those with good prognosis[(49.67±4.16%),(50.33±2.55)mm;(52.44±2.77)mm,(43.76±3.31)mm,(5.44±3.34)mg/L],with statistically significant differences(P<0.05).Upon admission,LVEDD,LVESD and serum hs-CRP parameters were identified as risk factors for poor prognosis,while LVEF and LVEDV parameters were pro

关 键 词：超声心动图参数 HSCRP 慢性心力衰竭 近期预后 

分 类 号：R540.45[医药卫生—心血管疾病] R541.6[医药卫生—内科学]