介入治疗干预在颅内动脉瘤患者中的应用效果及对血液流变学的影响研究  

Study on the application effect of interventional therapy and its impact on hemorheology in patients with intracranial aneurysms

作　　者：刘鹏飞 贾晓彤[2] LIU Pengfei;JIA Xiaotong(Department of Neurosurgery,Jiyuan People's Hospital,Jiyuan 459000,China;School of Medical Nursing,Jiyuan Vocational and Technical College,Jiyuan 459000,China)

机构地区：[1]济源市人民医院神经外科,河南济源459000 [2]济源职业技术学院医学护理学院,河南济源459000

出　　处：《黑龙江医药科学》2025年第1期31-34,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关计划项目,编号:LHGJ20220337。

摘　　要：目的:探讨介入治疗干预在颅内动脉瘤患者中的应用效果及对血液流变学的影响。方法:前瞻性选取2021年5月至2023年4月济源市人民医院收治的颅内动脉瘤患者96例为对象,信封法分为两组,各48例。对照组采用开颅手术治疗,观察组采用介入治疗干预,两组术后7d评价患者效果,比较两组血液流变学、血管内皮功能、炎症因子指标及并发症发生率。结果:两组干预后血液流变学水平得到降低;观察组血浆黏度、高切黏度与低切黏度水平低于对照组(P<0.05);两组干预后均伴有不同程度血管内皮功能损伤;观察组ET-1低于对照组(P<0.05);vWF及NO高于对照组(P<0.05);观察组干预后CRP、IL-2、IL-6及IL-8低于对照组(P<0.05);两组安全性比较无统计差异(P>0.05)。结论:介入治疗干预用于颅内动脉瘤患者中,有助于改善患者血液流变学水平,对血管内皮功能影响较小,能降低炎症因子水平,未增加术后并发症发生率。Objective:To investigate the application effect of interventional therapy in patients with intracranial aneurysms and its impact on hemorheology.Methods:A total of 96 patients with intracranial aneurysms admitted to Jiyuan People's Hospital in Henan Province from May 2021 to April 2023 were prospectively selected and divided into two groups with 48 patients in each group using the envelope method.The control group underwent craniotomy surgery,while the observation group underwent interventional therapy.The outcomes of the patients in both groups were evaluated 7 days after surgery,and the hemorheology,vascular endothelial function,inflammatory factors and complication rates were compared between the two groups.Results:The hemorheological levels decreased after intervention in both groups;the plasma viscosity,high-shear viscosity and low-shear viscosity levels in the observation group were lower than those in the control group(P<0.05).Both groups exhibited varying degrees of vascular endothelial function damage after intervention;The ET-1 level in the observation group was lower than that in the control group(P<0.05),whereas the vWF and NO levels were higher than those in the control group(P<0.05).CRP,IL-2,IL-6 and IL-8 levels were lower in the observation group than in the control group after intervention(P<0.05).No statistical difference in safety was found between the two groups(P>0.05).Conclusion:Interventional therapy for patients with intracranial aneurysms helps improve hemorheological levels,reduces the impact on vascular endothelial function,decreases inflammatory factor levels,and does not increase the incidence of postoperative complications,thus making it worthy of promotion and application.

关 键 词：介入治疗干预 开颅手术 颅内动脉瘤 血液流变学 血管内皮功能 炎症因子 并发症 

分 类 号：R651.12[医药卫生—外科学]