颈动脉超声参数及血清膜联蛋白A2水平与冠心病患者冠状动脉狭窄程度的相关性分析及临床意义  

Correlation analysis and clinical significance of carotid ultrasound parameters and serum Annexin A2 level with the degree of coronary artery stenosis in patients with coronary heart disease

作　　者：侯琼 崔存英 黄丹青 HOU Qiong;CUI Cunying;HUANG Danqing(Department of Ultrasound,Xinzheng Huaxin Minsheng Hospital,Xinzheng 451100,China;Department of Ultrasound,Fuwai Central China Cardiovascular Hospital,Zhongmu 451450,China)

机构地区：[1]新郑华信民生医院超声科,河南新郑451100 [2]阜外华中心血管医院超声科,郑州中牟451450

出　　处：《黑龙江医药科学》2025年第1期110-113,共4页Heilongjiang Medicine and Pharmacy

基　　金：河南省医学科技攻关联合共建项目,编号:LHGJ20217841。

摘　　要：目的:探讨冠心病患者血清膜联蛋白A2(ANXA2)、颈动脉超声参数水平与冠状动脉狭窄程度的相关性,并分析其临床意义。方法:回顾性选取2021年7月至2024年2月新郑华信民生医院104例冠心病患者为研究对象,根据冠状动脉狭窄程度分为轻度狭窄组(n=39)、中重度狭窄组(n=65)。对比两组临床一般资料、颈动脉超声参数[颈动脉硬化度(β)、颈动脉顺应性(AC)、弹性系数(Ep)、颈动脉中膜厚度(IMT)]及血清ANXA2水平,并分析其相关性、其水平检测在重度冠状动脉狭窄中的诊断效能及危险度。结果:中重度狭窄组左室舒张末内径(LVEDD)、左室收缩末内径(LVESD)水平均高于轻度狭窄组,左室射血分数(LVEF)水平均低于轻度狭窄组(P<0.05);轻度狭窄组参数β、Ep、AC、IMT、ANXA2水平均高于中重度狭窄组(P<0.05);参数β、Ep、AC、IMT、ANXA2均与心动图参数LVEDD、LVESD呈正相关,与参数LVEF均呈负相关(P<0.05);入院时颈动脉超声参数及血清ANXA2水平联合诊断中重度狭窄的曲线下面积(AUC)为0.784,最佳敏感度、特异度分别为76.92%、78.46%。入院时颈动脉超声参数及血清ANXA2高水平患者发生预后不良的危险度是低水平1.728、1.741、1.898、1.929、1.955倍(P<0.05)。结论:冠心病患者血清ANXA2、颈动脉超声参数水平与病变严重程度相关,可作为早期判断病情程度的有效手段。Objective:To investigate the correlation between serum Annexin A2(ANXA2)levels and carotid artery ultrasound parameters with the degree of coronary artery stenosis in patients with coronary heart disease,and to analyze its clinical significance.Methods:A retrospective study was conducted on 104 coronary heart disease patients from July 2021 to February 2024 at Xinzheng Huaxin Minsheng Hospital.The patients were divided into mild stenosis group(n=39)and moderate-to-severe stenosis group(n=65)based on the degree of coronary artery stenosis.Clinical general information,carotid artery ultrasound parameters[carotid artery stiffness(β),carotid artery compliance(AC),elastic modulus(Ep),carotid intima-media thickness(IMT)]and serum ANXA2 levels were compared between the two groups,and their correlations were analyzed.The diagnostic efficacy and risk assessment of these parameters in severe coronary artery stenosis were also evaluated.Results:The left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were higher,while the left ventricular ejection fraction(LVEF)was lower in the moderate-to-severe stenosis group compared to the mild stenosis group(P<0.05).The carotid artery ultrasound parameters ofβ,Ep,AC,IMT and serum ANXA2 levels were higher in the mild stenosis group than in the moderate-to-severe stenosis group(P<0.05).The parameters ofβ,Ep,AC,IMT,ANXA2 were positively correlated with echocardiographic parameters LVEDD and LVESD,and negatively correlated with LVEF(P<0.05).The area under the curve(AUC)for the combined diagnosis of moderate to severe stenosis using carotid ultrasound parameters and serum ANXA2 levels at admission was 0.784,with optimal sensitivity and specificity of 76.92%and 78.46%,respectively.The risk of adverse prognosis was 1.728,1.741,1.898,1.929 and 1.955 times higher in patients with high levels of carotid artery ultrasound parameters and serum ANXA2 at admission compared to those with low levels(P<0.05).Conclusion:Serum ANXA2 levels and carotid artery u

关 键 词：颈动脉超声参数 AnnexinⅡ 冠心病 冠状动脉狭窄 

分 类 号：R445[医药卫生—影像医学与核医学] R541[医药卫生—诊断学]