老年高血压患者颈动脉硬化与血清超敏C反应蛋白、脂蛋白(a)及尿酸的相关性  

Correlation between carotid Arteriosclerosis and serum high-sensitivity C-reactive protein,lipoprotein(a)and uric acid in elderly hypertensive patients

作　　者：严新美 黎兰芳 万红梅 YAN Xin-Mei;LI Lan-Fang;WAN Hong-Mei(General Practice Department,Xinyu People′s Hospital,Xinyu 338000,Jiangxi,China)

机构地区：[1]新余市人民医院全科医学科,江西新余338000

出　　处：《吉林医学》2025年第1期24-27,共4页Jilin Medical Journal

基　　金：新余市科技计划项目[项目编号:20213090820]。

摘　　要：目的:探讨老年高血压患者颈动脉硬化与血清超敏C反应蛋白(hs-CRP)、脂蛋白(a)及尿酸(UA)的相关性。方法:选取2021年1月~2022年12月新余市人民医院收治的180例原发性高血压患者作为研究对象,按照彩超结果分为内膜正常组(50例)、内膜增厚组(60例)、斑块形成组(70例)。观察一般资料、hs-CRP、脂蛋白(a)、UA水平、颈动脉硬化和生化指标的相关因素。结果:内膜增厚组、斑块形成组、内膜正常组三组患者的年龄、性别比较,差异无统计学意义(P>0.05);内膜增厚组和斑块形成组的hs-CRP、脂蛋白(a)、UA水平均高于对照组,差异有统计学意义(P<0.05);斑块形成组hs-CRP、脂蛋白、UA水平均高于内膜增厚组,差异有统计学意义(P<0.05);将IMT作为因变量,其他三个指标为自变量,经多因素Logistic回归分析显示,三者均为颈动脉内膜中层厚度增加的独立危险因素[hs-CRP:OR=2.383,95%CI=1.403~4.033,P=0.004;脂蛋白(a):OR=2.579,95%CI=1.084~4.748,P=0.029;UA:OR=2.511,95%CI=1.001~4.796,P=0.000];三组间相关性分析显示,任意两两指标正相关[hs-CRP和脂蛋白(a),r=0.665,P<0.05;hs-CRP和UA,r=0.714,P<0.05;脂蛋白(a)和UA,r=0.698,P<0.05]。结论:老年高血压患者颈动脉硬化与血清hs-CRP、脂蛋白(a)及UA呈相关性,这些因素均是影响患者发病的独立危险因素,临床需引起足够的重视。Objective To investigate the correlation between carotid Arteriosclerosis and serum high-sensitivity C-reactive protein,lipoprotein(a)and uric acid in elderly hypertensive patients.Method 180 patients with essential hypertension admitted to the Xinyu People′s Hospital from January 2021 to December 2022 were selected as research objects.According to the results of color ultrasound,they were divided into three groups:normal endometrium group(50 cases),intimal thickening group(60 cases),and plaque formation group(70 cases).General information,high sensitivity CRP,lipoprotein(a),uric acid(BUA)level,carotid Arteriosclerosis and related factors of biochemical indicators were observed.Results The age and gender differences among the three groups of patients with endometrial thickening,plaque formation,and normal endometrium were not statistically significant(P>0.05);The levels of high sensitivity CRP,lipoprotein(a),and BUA in the endometrial thickening group and plaque formation group were higher than those in the control group,with statistical significance(P<0.05);The levels of high sensitivity CRP,lipoprotein(a),and BUA in the plaque formation group were higher than those in the endometrial thickening group,with statistical significance(P<0.05);Using IMT as the dependent variable and the other three indicators as independent variables,multivariate logistic regression analysis showed that all three were independent risk factors for increased carotid intima-media thickness[high sensitivity CRP,OR=2.383,95%CI=1.403~4.033,P=0.004;Lipoprotein(a),OR=2.579,95%CI=1.084~4.748,P=0.029;UA,OR=2.511,95%CI=1.001~4.796,P=0.000];Correlation analysis among the three groups showed a positive correlation between any two indicators[high sensitivity CRP and lipoprotein(a),r=0.665,P<0.05;High sensitivity CRP and UA,r=0.714,P<0.05;Lipoprotein(a)and uric acid,r=0.698,P<0.05].Conclusion Carotid Arteriosclerosis in elderly patients with hypertension is positively correlated with serum high-sensitivity C-reactive protein,lipoprotein(a)and uri

关 键 词：老年高血压 颈动脉硬化 血清高敏C-反应蛋白 脂蛋白(a) 尿酸 相关性 

分 类 号：R544.1[医药卫生—心血管疾病]