中药外敷联合小金胶囊在气郁痰阻型甲状腺结节的应用效果及对焦虑抑郁的影响  

The effect of External Application of Chinese Medicine Combined with Xiaojin Capsule on Thyroid Nodule with Qi Stagnation and Phlegm Obstruction and its Influence on Anxiety and Depression

作　　者：许春芳 方朝晖[1,2] 程梅 鲍陶陶[1] 盛凤霞[1] XU Chun-Fang;FANG Chao-Hui;CHENG Mei(Endocrinology Department of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,Anhui,China)

机构地区：[1]安徽中医药大学第一附属医院内分泌科,安徽合肥230031 [2]新安医学教育部重点实验室安徽中医药大学

出　　处：《吉林医学》2025年第1期141-145,共5页Jilin Medical Journal

基　　金：国家自然科学基金项目[项目编号:82174153;81573944];安徽省高校协同创新项目[项目编号:GXXT-2020-025]。

摘　　要：目的:研究中药外敷联合小金胶囊在气郁痰阻型甲状腺结节的应用效果及对焦虑抑郁的影响。方法:选取2021年4月~2022年11月安徽中医药大学第一附属医院内分泌科收治的气郁痰阻型甲状腺结节住院患者70例为研究对象,随机分为对照组与试验组各35例。对照组采用散结消肿、化瘀通络的小金胶囊,4粒/次,2次/d。试验组在对照组基础上予以夏慈消结散中药外敷,4~6 h/次,1次/d,两组均治疗12周。12周后比较两组患者中医证候量表评分、临床疗效、甲状腺最大直径变化、不良反应及焦虑抑郁状况的发生情况。结果:治疗后,试验组中医证候评分低于对照组,差异具有统计学意义(P<0.05);干预后试验组的临床疗效高于对照组,差异具有统计学意义(P<0.05);干预后试验组甲状腺结节最大直径低于对照组,差异具有统计学意义(P<0.05);干预后试验组焦虑、抑郁评分均较对照组下降,差异有统计学意义(P<0.05)。结论:夏慈消结散中药外敷联合小金胶囊能够改善气郁痰阻型甲状腺结节中医证候评分,提高临床疗效,缩小甲状腺结节大小,减轻患者焦虑抑郁状况的发生,操作方法简单、安全、无创,能够提高患者满意度。Objective To study the effect of external application of Chinese medicine combined with Xiaojin capsule on anxiety and depression of thyroid nodule with qi stagnation and phlegm obstruction.Method A total of 70 inpatients with Qi-depression and phlegm obstruction type thyroid nodules in the Department of Endocrinology of the First Affiliated Hospital of Anhui University of Traditional Chinese Medicine from April 2021 to November 2022 were selected as research object and randomly divided into control group(n=35)and experimental group(n=35).The control group was treated with Xiaojin capsule,which was used to remove swelling and blood stasis,twice a day,4 capsules each time.The experimental group was treated with external application of Xiaci Xiaojie powder on the basis of the control group,once a day,4 to 6 hours each time.Both groups were treated for 12 weeks.After 12 weeks,the TCM syndrome scale score,clinical efficacy,changes in the maximum diameter of thyroid,adverse reactions,and the incidence of anxiety and depression were compared between the two groups.Results After treatment,the TCM syndrome score of the experimental group was lower than that of the control group,with statistically significant difference(P<0.05).After intervention,the clinical efficacy of the experimental group was higher than that of the control group,with statistically significant difference(P<0.05).After intervention,the diameter of the maximum thyroid nodule in the experimental group was lower than that in the control group,with a statistical difference(P<0.05).After intervention,the anxiety and depression scores of the experimental group decreased compared to the control group,with a statistical difference(P<0.05).Conclusion Xiaci Xiaojie powder combined with Xiaojin capsule can improve the TCM syndrome score of thyroid nodules with qi stagnation and phsputum obstruction,improve the clinical efficacy,reduce the size of thyroid nodules,and reduce the occurrence of anxiety and depression in patients.The method is non-invasive,simple and

关 键 词：中药外敷 夏慈消结散 小金胶囊 气郁痰阻证 甲状腺结节 

分 类 号：R581[医药卫生—内分泌]