左西孟旦联合沙库巴曲缬沙坦、曲美他嗪治疗心力衰竭的效果  

Study on the efficacy of levosimendan combined with sacubactrosovalsartan and trammetazidine in patients with heart failure

作　　者：刘秋霞[1] LIU Qiu-Xia(Cardiovascular Department of Qinzhou Second People′s Hospital,Qinzhou 535000,Guangxi,China)

机构地区：[1]钦州市第二人民医院心血管内科,广西钦州535000

出　　处：《吉林医学》2025年第1期145-148,共4页Jilin Medical Journal

基　　金：广西壮族自治区自然科学基金项目[项目编号:20233124]。

摘　　要：目的:探究左西孟旦联合沙库巴曲缬沙坦、曲美他嗪对心力衰竭(HF)患者的治疗效果。方法:纳入2023年3月~2024年2月钦州市第二人民医院收治的85例HF患者采用随机摸球法分为对照组42例和研究组43例,对照组采用沙库巴曲缬沙坦联合曲美他嗪治疗,研究组结合左西孟旦治疗。比较两组临床治疗效果、心功能[左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)、左心室短轴缩短率(FS)、左心室舒张期内径(LVEDD)]、心肌损伤标志物[肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnI)、脑钠肽(BNP)]、不良反应(腹痛、腹泻、皮疹)。结果:研究组临床治疗总有效率(97.67%)高于对照组(85.71%),差异有统计学意义(P<0.05)。治疗前两组心功能水平比较差异无统计学意义(P>0.05);治疗后研究组LVESD、LVEDD水平低于对照组,LVEF、FS水平高于对照组,差异均有统计学意义(P<0.05)。治疗前两组心肌损伤标志物水平比较差异无统计学意义(P>0.05);治疗后研究组心肌损伤标志物水平低于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:左西孟旦联合沙库巴曲缬沙坦、曲美他嗪治疗HF具有较高临床疗效,能够改善患者心功能,降低心肌损伤标志物水平,且不良反应风险较低。Objective To explore the efficacy of levosimendan combined with valsartan and trmetazidine in patients with heart failure(HF).Method 85 HF patients admitted to Qinzhou Second People′s Hospital from March 2023 to February 2024 were included,they were divided into the control group 42 cases and the study group 43 cases by random touch ball method.The control group was treated with sacubaprotrosovalsartan combined with trimetazidine,and the study group was combined with levosimendan.Comparing the two groups of clinical efficacy,cardiac function[left ventricular end-systolic inner diameter(Left Ventricular End-Systolic Diameter,LVESD),left ventricular ejection fraction(Left Ventricular Ejection Fraction,LVEF),LV short axis shortening rate(Fractional Shortening,FS),left ventricular diastolic inner diameter(Left Ventricular End-Diastolic Diameter,LVEDD)],markers of myocardial injury[creatine kinase(creatine kinase,CK),creatine kinase isozymes(creatine kinase isoenzymes,CK-MB),Troponin I(cardiac troponin I,The cTnI),BNP peptide(brain natriuretic peptide,BNP)],adverse effects[abdominal pain,diarrhea,skin rash].Results The total effective rate of clinical treatment in the study group was 97.67%,which was higher than the control group′s 85.71%,and the difference was statistically significant(P<0.05).There was no statistically significant difference in heart function levels between the two groups before treatment(P>0.05);After treatment,the levels of LVESD and LVEDD in the study group were lower than those in the control group,while the levels of LVEF and FS were higher than those in the control group,with statistical significance(P<0.05).There was no statistically significant difference in the levels of myocardial injury markers between the two groups before treatment(P>0.05);After treatment,the levels of myocardial injury markers in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of

关 键 词：左西孟旦 沙库巴曲缬沙坦 曲美他嗪 心力衰竭 心功能 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]