盐酸二甲双胍与阿卡波糖对糖尿病患者的治疗效果对比  

Comparison of Therapeutic Effect of Metformin Hydrochloride and Acarbose in Diabetic Patients

作　　者：熊小峰 李素云 XIONG Xiaofeng;LI Suyun(Department of Pharmacy,Huaqiao University Hospital,Xiamen,Fujian 361000,China)

机构地区：[1]华侨大学医院药剂科,福建厦门361000

出　　处：《中国医药指南》2025年第2期112-114,共3页Guide of China Medicine

摘　　要：目的对比分析盐酸二甲双胍与阿卡波糖对糖尿病患者的治疗效果。方法选取华侨大学医院102例2型糖尿病(T2DM)患者资料,将采用阿卡波糖治疗的51例患者列为观察组,将采用盐酸二甲双胍治疗的51例患者列为对照组。比较两组疗效、血糖指标(空腹血糖、糖化血红蛋白、餐后2 h血糖)、胰岛功能指标(胰岛素抵抗指数、胰岛β细胞功能指数)、血脂指标[三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)]及不良反应。结果对照组总有效率与观察组比较,差异无统计学意义(P>0.05)。对照组治疗后空腹血糖、TG、TC低于观察组,餐后2 h血糖、HDL-C高于观察组(P<0.05)。两组糖化血红蛋白、胰岛素抵抗指数、胰岛β细胞功能指数比较,差异无统计学意义(P>0.05)。对照组不良反应总发生率与观察组比较,差异无统计学意义(P>0.05)。结论盐酸二甲双胍与阿卡波糖应用于T2DM患者治疗均可有效降低血糖,改善胰岛功能,且安全性高,其中盐酸二甲双胍在控制空腹血糖、改善血脂方面更具优势,阿卡波糖在控制餐后2 h血糖方面更具优势。Objective To compare and analyze the therapeutic effect of metformin hydrochloride and acarbose on diabetic patients.Methods The data of 102 patients with type 2 diabetes mellitus(T2DM)in Huaqiao University hospital were retrospectively collected.51 patients treated with acarbose were classified as acarbose group and 51 patients treated with metformin hydrochloride as metformin group.The efficacy,blood glucose indexes(fasting blood glucose,glycated hemoglobin,2 h postprandial blood glucose),islet function indexes(insulin resistance index,islet beta cell function index),lipid indexes[triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)]and adverse reactions were compared between the two groups.Results The overall effectiveness of the control group compared with the observation group showed no statistically significant difference(P>0.05).After treatment,the control group had lower fasting blood glucose,TG and TC than the observation group,while the postprandial 2-hour blood glucose and HDL-C were higher than the observation group(P<0.05).The comparison of glycated hemoglobin,insulin resistance index,and pancreatic beta-cell function index between the two groups showed no statistically significant difference(P>0.05).The incidence of adverse reactions in the control group compared with the observation group showed no statistically significant difference(P>0.05).Conclusions Metformin hydrochloride and acarbose in the treatment of T2DM patients can effectively reduce blood glucose and improve islet function with high safety,among which metformin hydrochloride has more advantages in controlling fasting blood glucose and improving blood lipid,and acarbose has more advantages in controlling blood glucose 2 h after meals.

关 键 词：2型糖尿病 盐酸二甲双胍 阿卡波糖 胰岛功能 血糖 效果对比 

分 类 号：R587.1[医药卫生—内分泌]