血清25(OH)D3、8-OHdG与阻塞性睡眠呼吸暂停综合征患者轻度认知功能障碍的关系  

Analysis of the Correlation Between Serum 25(OH)D3 and 8-OHdG Levels and Mild Cognitive Impairment in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

作　　者：李洁 胡彪 Li Jie;Hu Biao(Department of Respiratory and Critical Care,Xi'an No.9 Hospital,Xi'an 710054,China;Department of Neurosurgery,The 986th Hospital of People's Liberation Army Air Force,Xi'an 710054,China)

机构地区：[1]西安市第九医院呼吸与危重症医学科,西安710054 [2]中国人民解放军空军第九八六医院神经外科,西安710054

出　　处：《成都医学院学报》2025年第1期41-45,共5页Journal of Chengdu Medical College

基　　金：陕西省科学技术厅重点研发计划项目(No:2018SF-211)。

摘　　要：目的探究血清25-羟维生素D3[25(OH)D3]、8-羟基脱氧鸟苷酸(8-OHdG)与阻塞性睡眠呼吸暂停综合征(OSAHS)患者轻度认知功能障碍(MCI)的相关性。方法选择2022年6月至2024年6月于西安市第九医院就诊的OSAHS患者159例为疾病组,根据MCI诊断标准将疾病组患者分为MCI组107例和认知正常组52例,另选择159例健康者为健康组。Spearman分析OSAHS合并MCI患者血清25(OH)D3、8-OHdG水平与蒙特利尔认知评估量表(MoCA)评分的相关性,Logistic回归分析OSAHS患者发生MCI的影响因素,受试者工作特征(ROC)曲线分析血清25(OH)D3、8-OHdG对OSAHS患者发生MCI的预测价值。结果疾病组与健康组相比,血清25(OH)D3水平降低、8-OHdG水平升高(P<0.05);MCI组与认知正常组相比,血清25(OH)D3水平降低、8-OHdG水平升高(P<0.05);血清25(OH)D3与MoCA评分呈正相关,血清8-OHdG与MoCA评分呈负相关(r=0.374、-0.301,P<0.05);年龄、吸烟、氧饱和度<90%时间占总监测时间的百分比和8-OHdG是OSAHS患者发生MCI的危险因素,MoCA评分、总睡眠时间、25(OH)D3是OSAHS患者发生MCI的保护因素(P<0.05);血清25(OH)D3预测OSAHS患者发生MCI的曲线下面积(AUC)为0.829(95%CI:0.762~0.896),灵敏度为78.50%,特异度为80.77%,血清8-OHdG预测OSAHS患者发生MCI的AUC为0.817(95%CI:0.744~0.889),灵敏度为83.18%,特异度为82.69%,两者联合预测OSAHS患者发生MCI的AUC为0.908(95%CI:0.857~0.959),灵敏度为92.52%,特异度为78.85%,血清25(OH)D3、8-OHdG两者联合对OSAHS患者发生MCI的预测价值更好(P<0.05)。结论血清25(OH)D3降低、8-OHdG升高可增加OSAHS患者发生MCI的风险,血清25(OH)D3、8-OHdG对OSAHS患者发生MCI具有一定预测价值。Objective To investigate the correlation between serum 25-hydroxyvitamin D3[25(OH)D3]and 8-hydroxy-2'-deoxyguanosine(8-OHdG)levels and mild cognitive impairment(MCI)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods A total of 159 patients with OSAHS in Xi'an No.9 Hospital from June 2022 to June 2024 were include in the OSAHS group.They were further divided into the MCI group(n=107)and the normal cognition group(n=52)according to the diagnostic criteria of MCI.And 159 healthy subjects were selected as the healthy control group.Spearman analysis was utilized to analyze the correlation between serum 25(OH)D3 and 8-OHdG levels and Montreal Cognitive Assessment(MoCA)score in OSAHS patients with MCI.Logistic regression analysis was used to analyze the factors influencing the occurrence of MCI in OSAHS patients.And the predictive value of serum 25(OH)D3 and 8-OHdG for MCI in patients with OSAHS was analyzed by receiver operating characteristic(ROC)curve.Results Compared with the healthy control group,the OSAHS group exhibited decreased serum 25(OH)D3 level and increased serum 8-OHdG level(P<0.05).Compared with the normal cognition group,the MCI group showed a decrease in serum 25(OH)D3 level and an increase in serum 8-OHdG level(P<0.05).Serum 25(OH)D3 level was positively correlated with MoCA score,while serum 8-OHdG was negatively correlated with MoCA score(r=0.374,-0.301,P<0.05).Age,smoking,oxygen saturation<90%time as a percentage of total monitoring time,and serum 8-OHdG were risk factors for MCI in OSAHS patients,while MoCA score,total sleep time,and serum 25(OH)D3 were protective factors for MCI in OSAHS patients(P<0.05).The area under the curve(AUC)of serum 25(OH)D3 in predicting MCI in OSAHS patients was 0.829(95%CI:0.762-0.896),with a sensitivity of 78.50%and a specificity of 80.77%.The AUC of serum 8-OHdG in predicting MCI in OSAHS patients was 0.817(95%CI:0.744-0.889),with a sensitivity of 83.18%and a specificity of 82.69%.The AUC of the combined detection of serum 25(OH)D3 and 8-OHdG

关 键 词：阻塞性睡眠呼吸暂停综合征 轻度认知功能障碍 25-羟维生素D3 8-羟基脱氧鸟苷酸 

分 类 号：R766[医药卫生—耳鼻咽喉科]