血清NAMPT、PARP1联合对慢性心衰患者心血管事件的预测价值  

Predictive Value of Serum NAMPT Combined with PARP1 for Cardiovascular Events in Patients with Chronic Heart Failure

作　　者：李娟[1] 董瑞莹 王静 Li Juan;Dong Ruiying;Wang Jing(Department of Cardiovascular Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Ward 1 of Cardiovascular Disease,Xi'an No.5 Hospital,Xi'an 710082,China)

机构地区：[1]西安交通大学医学院第一附属医院心血管外科,西安710061 [2]西安市第五医院心血管一病区,西安710082

出　　处：《成都医学院学报》2025年第1期114-118,共5页Journal of Chengdu Medical College

摘　　要：目的探讨血清烟酰胺磷酸核糖转移酶(NAMPT)、聚腺苷酸二磷酸核糖聚合酶(PARP1)联合对慢性心衰(CHF)患者心血管事件的预测价值。方法选取2018年2月至2022年4月西安交通大学医学院第一附属医院收治的179例CHF患者作为试验组,根据随访期间有无发生心血管事件分为有事件组(n=55)和无事件组(n=124)。另选同时期体检的179例健康者作为对照组,采用酶联免疫吸附(ELISA)法检测血清NAMPT、PARP1水平;多因素Logistic回归分析CHF患者发生心血管事件的影响因素;ROC曲线分析血清NAMPT、PARP1水平对CHF患者心血管事件的预测价值。结果对照组血清NAMPT、PARP1水平低于试验组(P<0.05);有事件组血清N末端B型脑钠肽前体(NT-ProBNP)水平、心率、血清NAMPT、PARP1水平高于无事件组,左心室射血分数(LVEF)水平低于无事件组(P<0.05);Ⅳ级患者血清NAMPT、PARP1水平高于Ⅲ级、Ⅱ级患者(P<0.05),Ⅲ级患者血清NAMPT、PARP1水平高于Ⅱ级患者(P<0.05);血清NT-ProBNP、LVEF、心率、NAMPT、PARP1为CHF患者发生心血管事件的影响因素(P<0.05);血清NAMPT、PARP1水平联合预测CHF患者心血管事件的曲线下面积(AUC)为0.939,敏感度和特异度分别为96.36%、79.03%,优于各自单一诊断(Z_(二者联合-NAMPT)=3.571、Z_(二者联合-PARP1)=2.699,P<0.001、P<0.001)。结论CHF患者血清NAMPT、PARP1水平明显升高,与发生心血管事件密切相关,二者为CHF患者发生心血管事件的影响因素,二者联合对CHF患者心血管事件具有较高的预测价值。Objective To explore the predictive value of serum nicotinamide phosphoribosyltransferase(NAMPT)combined with serum polyadenylate diphosphate ribose polymerase(PARP1)for cardiovascular events in patients with chronic heart failure(CHF).Methods A total of 179 patients with CHF admitted to the First Affiliated Hospital of Xi'an Jiaotong University from February 2018 to April 2022 were included in the experimental group.They were further grouped into an event group(n=55)and an event-free group(n=124)based on the occurrence of cardiovascular events during the follow-up period.Meantime,179 healthy individuals who underwent physical examinations were included as the control group.Enzyme-linked immunosorbent assay(ELISA)was applied to detect the levels of serum NAMPT and PARP1.Multivariate Logistic regression analysis was utilized to analyze the influencing factors of cardiovascular events in CHF patients.Receiver operator characteristic(ROC)curve was used to analyze the predictive value of serum NAMPT and PARP1 levels for cardiovascular events in CHF patients.Results The levels of serum NAMPT and PARP1 in the control group were lower than those in the experimental group(P<0.05).The serum N-terminal pro-B-type brain natriuretic peptide(NT-ProBNP)level,heart rate,and serum NAMPT and PARP1 levels in the event group were higher than those in the event-free group,while the left ventricular ejection fraction(LVEF)level in the event group was lower than that in the event-free group(P<0.05).The levels of serum NAMPT and PARP1 in gradeⅣpatients were higher than those in gradeⅢandⅡpatients(P<0.05),and the levels of serum NAMPT and PARP1 in gradeⅢpatients were higher than those in grade II patients(P<0.05).Serum NT-ProBNP,LVEF,heart rate,NAMPT,and PARP1 were influencing factors for the occurrence of cardiovascular events in CHF patients(P<0.05).The area under the curve(AUC)of the combined prediction of serum NAMPT and PARP1 levels for cardiovascular events in CHF patients was 0.939,with a sensitivity and a specificity of

关 键 词：烟酰胺磷酸核糖转移酶 聚腺苷酸二磷酸核糖聚合酶 慢性心衰 心血管事件 预测 

分 类 号：R541.6[医药卫生—心血管疾病]