人表皮生长因子联合湿润烧伤膏治疗烧伤患儿的效果  

Effects of human epidermal growth factor combined with moisture exposed burn ointment in treatment of burn children

作　　者：姜海洋 杨洪 马常明 JIANG Haiyang;YANG Hong;MA Changming(Department of Burn and Severe Burn of Nanyang Nanshi Hospital,Nanyang 473000 Henan,China)

机构地区：[1]南阳南石医院烧伤科及烧伤重症病区,河南南阳473000

出　　处：《中国民康医学》2025年第1期64-66,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察人表皮生长因子联合湿润烧伤膏治疗烧伤患儿的效果。方法:选取2022年5月至2023年10月该院收治的90例烧伤患儿进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各45例。对照组给予湿润烧伤膏治疗,研究组在对照组基础上联合人表皮生长因子治疗。比较两组临床疗效,创面愈合时间和红斑持续时间,治疗前后炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-8(IL-8)]、T细胞亚群指标(CD3^(+)、CD4^(+)、CD8^(+))水平,以及不良反应发生率。结果:研究组治疗总有效率为88.89%(40/45),高于对照组的71.11%(32/45),差异有统计学意义(P<0.05);治疗后,两组TNF-α、IL-2、IL-8水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组创面愈合时间、红斑持续时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组CD3^(+)、CD4^(+)水平均高于治疗前,且研究组高于对照组,两组CD8^(+)水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:人表皮生长因子联合湿润烧伤膏治疗烧伤患儿可提高治疗总有效率,缩短创面愈合时间和红斑持续时间,改善T细胞亚群指标水平,以及降低炎性因子水平的效果优于单纯湿润烧伤膏治疗。Objective:To observe effects of human epidermal growth factor combined with moisture exposed burn ointment in treatment of burn children.Methods:A prospective study was conducted on 90 children with burns admitted to this hospital from May 2022 to October 2023.According to the random number table method,they were divided into control group and study group,45 cases in each group.The control group was treated with moisture exposed burn ointment,while the study group was treated with human epidermal growth factor on the basis of that of the control group.The clinical efficacy,the wound healing time,the erythema duration,the levels of inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),interleukin-8(IL-8)]and T cell subsets(CD3^(+),CD4^(+),CD8^(+))before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the study group was 88.89%(40/45),which was higher than 71.11%(32/45)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of TNF-α,IL-2 and IL-8 in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The wound healing time and the erythema duration in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD3^(+)and CD4^(+)in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the levels of CD8^(+)in the two groups were lower than those before the treatment,and that in the study group was lower than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Human epidermal growth factor combined with m

关 键 词：人表皮生长因子凝胶 湿润烧伤膏 烧伤 炎性因子 不良反应 

分 类 号：R541.6[医药卫生—心血管疾病]