卵圆孔未闭封堵器材料研究进展  

Research progress on materials of patent foramen ovale occlader

作　　者：周广泰 周超 张海军 ZHOU Guang-tai;ZHOU Chao;ZHANG Hai-jun(National United Engineering Laboratory for Biomedical Material Modifi cation,Branden Industrial Park,Qihe Economic&Development Zone,Dezhou 251100,China;Department of Interventional and Vascular Surgery,the Tenth People’s Hospital of Shanghai,Tongji University,Shanghai 200072,China)

机构地区：[1]生物医用材料改性技术国家地方联合工程实验室,山东德州251100 [2]同济大学附属第十人民医院介入血管研究所,上海200072

出　　处：《中国介入心脏病学杂志》2024年第12期709-716,共8页Chinese Journal of Interventional Cardiology

基　　金：国家自然科学基金项目(82270535)。

摘　　要：卵圆孔未闭(PFO)是心源性脑卒中的重要危险因素,随着心脏介入技术的快速发展,PFO封堵器已成为治疗PFO的首选方法。封堵器材料的生物相容性、机械稳定性及其与患者解剖结构的适应性是决定治疗效果的关键因素,其研究取得了显著进展,早期封堵器主要采用金属材质,虽具有较高的封堵效果和操作便捷性,但存在长期留存体内的潜在风险。近年来,生物可降解材料在封堵器领域得到广泛应用,这类封堵器采用生物医用高分子材料制成,置入人体后起到临时桥梁作用,引导自体组织生物修复,并逐步降解为无害物质排出体外,避免了金属封堵器的长期留存问题。本文综述了PFO封堵器材料的研究进展,包括不可降解材料和生物可降解材料的应用,并探讨了当前研究的局限性和未来可能的发展趋势,为临床应用提供参考。Patent foramen ovale(PFO)is an important risk factor for cardiogenic stroke.With the rapid development of cardiac interventional techniques,PFO occluder has become the fi rst choice for the treatment of PFO.The biocompatibility,mechanical stability of the occluder material and its adaptability to the patient's anatomical structure are key factors in determining the therapeutic effect.Remarkable progress has been made in its research.In the early stage,the occluder was mainly made of metal material.Although it has high sealing eff ect and operation convenience,there is potential risk of long-term retention in the body.In recent years,biodegradable materials have been widely used in the field of sealers,such sealers are made of biomedical polymer materials,implanted into the human body to play a temporary bridge role,guide self-tissue bioremediation,and gradually degrade into harmless substances discharged from the body,avoiding the long-term retention of metal sealers.This paper reviews the research progress of PFO occluder materials,including the application of non-degradable materials and biodegradable materials,and discusses the limitations of the current research and the possible development trend in the future,so as to provide reference for clinical application.

关 键 词：卵圆孔未闭封堵器 不可降解材料 生物可降解材料 

分 类 号：R541[医药卫生—心血管疾病]