血管平滑肌细胞内质网应激与蛋白质质量控制失调在动脉粥样硬化中的作用研究进展  

Advances in research on the effect of endoplasmic reticulum stress and dysregulation of protein quality control in vascular smooth muscle cells in atherosclerosis

作　　者：袁建 彭志强 华宁 林乐健 YUAN Jian;PENG Zhiqiang;HUA Ning;LIN Lejian(Department of Cardiovascular Medicine,the 8th Medical Center,Chinese PLA General Hospital,Beijing 100091,China;State Key Laboratory of Medical Proteomics,Beijing Institute of Biological Science,Beijing 100850,China)

机构地区：[1]中国人民解放军总医院第八医学中心心血管内科,北京100091 [2]北京生命科学研究所医学蛋白质组全国重点实验室,北京100850

出　　处：《新乡医学院学报》2025年第1期74-78,共5页Journal of Xinxiang Medical University

基　　金：国家自然科学基金项目(编号:82171857)。

摘　　要：动脉粥样硬化是心血管疾病的重要病理基础。血管平滑肌细胞的内质网应激与蛋白质质量控制的失调在动脉粥样硬化的发生发展中起着关键作用。内质网应激通过未折叠蛋白反应来调控蛋白质折叠、降解和自噬等过程,在这一过程中可能会导致细胞凋亡、自噬抑制、炎症反应等,进而加速动脉粥样硬化的进程。本文就近年来关于动脉粥样硬化中血管平滑肌细胞内质网应激与蛋白质质量控制的相关研究进行综述,总结氧化应激、脂质代谢失调等潜在的分子机制及精准靶向治疗动脉粥样硬化策略的重要性,以期为心血管疾病的防治提供参考。Atherosclerosis is an important pathological basis of cardiovascular diseases.Endoplasmic reticulum stress and dysregulation of protein quality control in vascular smooth muscle cells play a key role in the occurrence and progression of atherosclerosis.Endoplasmic reticulum stress regulates protein folding,degradation,and autophagy through the unfolded protein response,which may lead to cell apoptosis,autophagy inhibition,and inflammatory response,further accelerating the process of atherosclerosis.In this paper,recent progress in research on endoplasmic reticulum stress and dysregulation of protein quality control in vascular smooth muscle cells is systematically summarized.Moreover,potential molecular mechanisms of oxidative stress and dysregulation of lipid metabolism are summarized,and the importance of strategies precisely targeting the treatment of atherosclerosis is emphasized,so as to provide reference for the prevention and treatment of cardiovascular diseases.

关 键 词：动脉粥样硬化 血管平滑肌细胞 内质网应激 蛋白质质量控制 

分 类 号：R541.4[医药卫生—心血管疾病]