B族溶血性链球菌感染与足月胎膜早破产妇阴道感染及妊娠结局的相关性  

The correlation of group B Streptococcus infection with vaginal infection and pregnancy outcome in pregnant women with full-term premature rupture of membranes

作　　者：黄韵 包向敏 吴可欣 黄正 HUANG Yun;BAO Xiangmin;WU Kexin;HUANG Zheng(Department of Clinical Laboratory,Hai'an People's Hospital,Nantong,Jiangsu 226600,China;不详)

机构地区：[1]海安市人民医院检验科,江苏南通226600 [2]海安市人民医院妇产科 [3]长沙市中医医院(长沙市第八医院)针灸康复科 [4]南京中医药大学针灸推拿学院•养生康复学院

出　　处：《中国微生态学杂志》2024年第11期1318-1322,1327,共6页Chinese Journal of Microecology

摘　　要：目的探讨B族溶血性链球菌(GBS)感染与足月胎膜早破产妇阴道感染及妊娠结局的相关性,为该类患者的治疗提供参考。方法选择2020年3月至2023年1月我院收治的128例足月胎膜早破产妇为研究对象,其中22例足月胎膜早破合并GBS感染患者纳入观察组,106例足月胎膜早破未合并GBS感染患者纳入对照组,分析两组患者阴道感染情况和阴道分泌物IL-6水平的相关性及其不良妊娠结局。结果观察组患者阴道分泌物IL-6水平高于对照组(t=5.228,P<0.001)。观察组患者滴虫性阴道炎及细菌性阴道病阳性率分别为13.64%(3/22)、18.18%(4/22),均显著高于对照组的0.94%(1/106)和3.77%(4/106),差异有统计学意义(χ^(2)=5.956、4.230,均P<0.05)。两组女性外阴阴道假丝酵母菌病阳性率差异无统计学意义(P>0.05)。观察组患者的不良妊娠结局(新生儿肺炎、胎儿窘迫、新生儿窒息、早产)发生率高于对照组(χ^(2)=15.618,P<0.001)。GBS、IL-6阳性产妇新生儿肺炎、新生儿窒息及胎儿窘迫发生率高于GBS、IL-6阴性产妇(χ^(2)=12.079、17.336、11.058,均P<0.05)。结论胎膜早破合并GBS感染会导致阴道感染风险和IL-6水平升高,IL-6有望成为预测不良妊娠结局的重要临床指标。Objective To explore the correlation of group B Streptococcus(GBS)infection with vaginal infection and pregnancy outcome in women with full-term premature rupture of membranes(FPROM),providing a reference for the treatment.Methods A total of 128 patients with FPROM admitted to our hospital from March 2020 to January 2023 were enrolled.Among them,22 patients with FPROM combined with GBS infection were included as the observation group,and 106 patients with FPROM without GBS infection were included as the control group.The correlation of vaginal infec-tion with vaginal fluid IL-6 and the adverse pregnancy outcomes were analyzed.Results The vaginal fluid IL-6 level in observation group was higher than in the control group(t=5.228,P<0.001).The positive rates of trichomonas vaginitis and bacterial vaginosis in observation group were 13.64%(3/22)and 18.18%(4/22)respectively,obviously higher than in the control group[0.94%(1/106),3.77%(4/106)]respectively(χ^(2)=5.956,4.230;all P<0.05).There was no obvious differ-ence in the positive rate of vulvovaginal candidiasis between the two groups(P>0.05).The incidences of adverse preg-nancy outcomes such as neonatal pneumonia,fetal distress,neonatal asphyxia and preterm birth in observation group were higher than those in control group(χ^(2)=15.618,P<0.001).The incidence rates of neonatal pneumonia,neonatal asphyxia and fetal distress in GBS and IL-6 positive parturients were higher than in GBS and IL-6 negative parturients(χ^(2)=12.079,17.336,11.058;all P<0.05).Conclusion Premature rupture of membranes combined with GBS infection can increase the risk of vaginal infection and IL-6 level,and IL-6 is expected to become an important clinical indicator for predicting ad-verse pregnancy outcomes.

关 键 词：胎膜早破 B族溶血性链球菌感染 阴道炎症 白细胞介素-6 

分 类 号：R714.7[医药卫生—妇产科学]