基因多态性与锰中毒关系的研究进展  

Advances in study of relationships between gene polymorphisms and manganese poisoning

作　　者：付佳雨 李岩 FU Jiayu;LI Yan(School of Public Health,Zunyi Medical University,Zunyi,Guizhou 563006,China)

机构地区：[1]遵义医科大学公共卫生学院,贵州遵义563006

出　　处：《环境与职业医学》2024年第11期1319-1324,共6页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金项目(82360638);贵州省教育厅创新群体项目(黔教合KY字[2021]020)。

摘　　要：职业锰中毒是我国重要的职业性疾病之一,其可致机体各器官造成不同程度的损伤,其中神经中毒尤为明显。单核苷酸多态性(SNP)是指一个种群中某一基因存在两种或多种等位基因的现象,这种遗传变异可能影响个体对环境毒素的敏感性,而大多数病例可能是由复杂的基因-环境相互作用引起的。近年研究表明,锰中毒发病机制与基因多态性密切相关,可通过影响代谢等途径改变机体对锰的易感性。本文就氧化应激、铁代谢、神经递质代谢、锌转运蛋白、帕金森、DNA损伤修复、钙离子转运ATP酶2C型成员2基因(ATP2C2)相关基因与锰中毒之间的关系进行综述,旨在探索影响锰中毒的关键多态性基因,为职业暴露所致锰中毒的具体机制研究及防治提供基因层面的见解。Occupational manganese poisoning is one of the most important occupational diseases in China,and it can cause different degrees of damage to various organs of the body,among which neurotoxicity is particularly obvious.Single nucleotide polymorphism(SNP)refers to the presence of two or more alleles of a gene in a population.This genetic variation may affect an individual's sensitivity to environmental toxins,and most cases may be caused by complex gene-environment interactions.Recent studies have shown that the pathogenesis of manganese poisoning is closely related to genetic polymorphisms,which can alter the body's susceptibility to manganese by affecting metabolism among other pathways.In this paper,we reviewed the relationships between genes related to oxidative stress,iron metabolism,neurotransmitter metabolism,zinc transporter,parkinsonism,DNA damage repair,calcium transporting ATPase type 2C member 2 and manganese poisoning,aiming to explore the key polymorphic genes affecting manganese poisoning and to provide genetic insights into the specific mechanisms of manganese poisoning caused by occupational exposure and its prevention and treatment.

关 键 词：锰中毒 职业暴露 基因多态性 氧化应激 铁代谢 神经递质代谢 锌转运蛋白 帕金森 

分 类 号：R12[医药卫生—环境卫生学]