维生素D水平对输卵管因素不孕患者IVF长方案助孕成功率的影响  

Influence of vitamin D level on the success rate of in vitro fertilization long protocol assisted pregnancy in patients with tubal factor infertility

作　　者：梁辉[1] 邢鹏[1] 宋影莹 韩晶[1] 王娜[1] 赵媛媛 陈英[1] LIANG Hui;XING Peng;SONG Yingying;HAN Jing;WANG Na;ZHAO Yuanyuan;CHEN Ying(Department of Reproductive Medicine,Baoding Maternal and Child Health Hospital,Baoding 071000,Hebei,China)

机构地区：[1]保定市妇幼保健院生殖医学科,河北保定071000

出　　处：《中国性科学》2025年第1期68-71,共4页Chinese Journal of Human Sexuality

基　　金：保定市科技计划项目(2241ZF085)。

摘　　要：目的探究维生素D水平对输卵管因素不孕患者体外受精(IVF)长方案助孕成功率的影响。方法回顾性分析保定市妇幼保健院2022年6月至2023年6月收治的167例行IVF长方案助孕的输卵管因素不孕患者的病历资料。根据25羟维生素D水平分为A组(维生素D水平缺乏,n=74例)、B组(维生素D水平不足,n=51例)和C组(维生素D水平充足,n=42例)。比较三组的基线资料[年龄、不孕年限、体重指数(BMI)、卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)、雌二醇(E_(2))、孕酮(P)、抗米勒管激素(AMH)]、促排卵情况[促性腺激素(Gn)总剂量、Gn天数和获卵数]、胚胎实验室指标[人绒毛膜促性腺激素(hCG)日内膜厚度、hCG日大卵泡数、可利用胚胎数、平均移植胚胎数]和助孕后妊娠结局。结果三组患者的年龄、不孕年限、BMI、FSH、LH、PRL、E_(2)、P、AMH比较,差异无统计学意义(P>0.05);三组Gn总剂量、Gn天数、获卵数、可利用胚胎数、优质胚胎数和优质胚胎率比较,差异无统计学意义(P>0.05);三组hCG日内膜厚度、hCG日大卵泡数、可利用胚胎数、平均移植胚胎数比较,差异无统计学意义(P>0.05);B组、C组临床妊娠率、生化妊娠率均高于A组(P<0.05),但B组、C组组间比较差异无统计学意义(P>0.05)。结论维生素D水平与输卵管因素不孕患者的卵巢功能和促排卵情况无显著相关性,但对IVF长方案助孕成功率存在一定影响。Objective To explore the influence of vitamin D level on the success rate of in vitro fertilization(IVF)long protocol assisted pregnancy in patients with tubal factor infertility.Methods The medical records of 167 patients with tubal factor infertility who received IVF long protocol assisted pregnancy in Baoding Maternal and Child Health Hospital from June 2022 to June 2023 were retrospectively analyzed.According to the level of 25-hydroxyvitamin D,the patients were divided into group A(vitamin D deficiency,n=74),group B(vitamin D insufficiency,n=51)and group C(vitamin D sufficiency,n=42).The baseline data[age,years of infertility,body mass index(BMI),basal follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E_(2)),progesterone(P),anti-Müllerian hormone(AMH)],ovulation induction status[total dose of gonadotropin(Gn),Gn days and number of oocytes retrieved],embryo laboratory indicators[endometrial thickness on human chorionic gonadotropin(hCG)day,number of large follicles on hCG day,number of available embryos,average number of transferred embryos]and pregnancy outcomes after assisted pregnancy were compared among the three groups.Results There were no statistical differences in comparing the age,years of infertility,BMI,FSH,LH,PRL,E_(2),P and AMH among the three groups(P>0.05).There were no statistical differences among the three groups when comparing the total dose of Gn,days of Gn,number of oocytes retrieved,number of available embryos,number of high-quality embryos and rate of high-quality embryos(P>0.05).There were no statistically significant differences in comparing the endometrial thickness on hCG day,number of large follicles on hCG day,number of available embryos and average number of transferred embryos number among the three groups(P>0.05).The clinical pregnancy rate and biochemical pregnancy rate in group B and group C were both higher than those in group A(P<0.05),but the difference in comparing groups B and C was not statistically significant(P>0.05).Conclusions Vitam

关 键 词：维生素D 输卵管 不孕 体外受精长方案助孕 成功率 

分 类 号：R711[医药卫生—妇产科学]