基于潜变量增长混合模型探讨IVF-ET患者心理症状与压力变化轨迹  

Investigation on change trajectories of psychological symptoms and stress in vitro fertilization-embryo transfer patients based on latent growth mixture model

作　　者：王盼盼 孙洪梅[3] 靳荣秀 包汉茹 王童玉 林冬霞[3] 王梦 WANG Panpan;SUN Hongmei;JIN Rongxiu;BAO Hanru;WANG Tongyu;LIN Dongxia;WANG Meng(Department of Nursing,Beijing University Shenzhen Hospital,Shenzhen 518000,Guangdong,China;Master Degree Candidate of Nursing in 2022,School of Nursing and Health,Henan University,Kaifeng 475000,Henan,China;Reproductive Medical Center,Beijing University Shenzhen Hospital,Shenzhen 518000,Guangdong,China)

机构地区：[1]北京大学深圳医院护理部,广东深圳518000 [2]河南大学护理与健康学院,河南开封475000 [3]北京大学深圳医院生殖医学中心,广东深圳518000

出　　处：《中国性科学》2025年第1期155-160,共6页Chinese Journal of Human Sexuality

基　　金：北京大学深圳医院科研项目(LCYJ2021045);广东省护士协会面上项目(gdshsxh2023ms07,gdshsxh2023ms74);深圳市“医疗卫生三名工程”资助项目(SZSM202111013)。

摘　　要：目的基于潜变量增长混合模型探讨体外受精-胚胎移植(IVF-ET)患者心理症状与压力变化轨迹及影响因素。方法选取2023年3月10日至2024年5月17日北京大学深圳医院收治的269例行IVF-ET的女性患者作为研究对象,采用基线资料调查表、心理症状与压力量表、社会支持评定量表(SSRS)在4个时间节点对患者进行调查。采用潜变量增长混合模型识别心理症状与压力变化轨迹,采用Logistic回归分析不同变化轨迹亚组的影响因素。结果治疗期间IVF-ET患者心理症状与压力存在3种轨迹,分别为持续上升组(C1,n=58)、持续低平组(C2,n=158)、持续下降组(C3,n=53)。年龄、社会支持利用度评分、工作、原发性不孕是C1的独立影响因素(P<0.05),原发性不孕、不孕为双方原因是C3的独立影响因素(P<0.05)。结论治疗期间IVF-ET患者心理症状与压力变化轨迹存在群体异质性,应基于不同变化轨迹进行针对性评估和心理支持。Objective To investigate the change trajectories and influencing factors of psychological symptoms and stress among patients undergoing in vitro fertilization-embryo transfer(IVF-ET)based on latent growth mixture modeling.Methods A total of 269 female patients undergoing IVF-ET at Beijing University Shenzhen Hospital between March 10,2023,and May 17,2024,were included as study objects.Data were collected at four time points using baseline demographic questionnaires,psychological symptom and stress scales,and the social support rating scale(SSRS).Latent growth mixture modeling was employed to identify change trajectories of psychological symptoms and stress.Logistic regression analysis was conducted to examine the influencing factors associated with different change trajectory subgroups.Results Three trajectories of psychological symptoms and stress were identified during the treatment period:a persistently increasing group(C1,n=58),a consistently low-level group(C2,n=158),and a persistently decreasing group(C3,n=53).Age,utilization score of social support,employment status,primary infertility were independent influencing factors of C1(P<0.05),primary infertility and bilateral infertility causes were found to be independent influencing factors for C3(P<0.05).Conclusions The study reveals that there is significant heterogeneity in the change trajectories of psychological symptoms and stress among IVF-ET patients during treatment.Targeted assessments and psychological support should be provided based on these different change trajectories to better address individual needs.

关 键 词：潜变量增长混合模型 体外受精-胚胎移植 影响因素 

分 类 号：R395[哲学宗教—心理学]