海藻酸钠稳定金纳米簇的肾脏清除  

Renal Clearance of Sodium Alginate Stabilized Au Nanoclusters

作　　者：王天缘 张华真 赵聘 王凯 林敏 WANG Tianyuan;ZHANG Huazhen;ZHAO Pin;WANG Kai;LIN Min(College of Materials Science and Engineering,Qingdao University,Qingdao 266071,China;Wuhu Industrial Innovation Center,Wuhu 241000,China)

机构地区：[1]青岛大学材料科学与工程学院,青岛266071 [2]芜湖市产业创新中心,芜湖241000

出　　处：《高等学校化学学报》2025年第1期172-179,共8页Chemical Journal of Chinese Universities

基　　金：山东省自然科学基金(批准号:ZR2019BEM044);山东省泰山学者项目(批准号:tsqn201812050)资助.

摘　　要：使用生物相容性良好的海藻酸钠作为金纳米簇的配体,制备了细胞毒性极低的海藻酸钠稳定的金纳米簇,其尺寸为(4.2±0.9)nm.海藻酸钠配体通过延缓金纳米簇的肾脏代谢过程,将金纳米簇的血液循环半衰期延长至(8.2±0.2)h,并将肿瘤的摄取效率提高到10.4%ID/g;当肿瘤区域存在高浓度的钙离子时,其与海藻酸钠的交联可将肿瘤摄取效率进一步提高到14.5%ID/g.通过对小鼠排泄物的监测,证明了金纳米簇主要通过肾脏过滤,经过尿液排出体外,代谢过程仅对肾功能产生可恢复的微小干扰,表明海藻酸钠稳定的金纳米簇具备良好的生物安全性.本文通过对配体功能性的探索,解决了纳米簇在生物安全性与肿瘤治疗效率之间的矛盾,也为其它高性能纳米诊疗试剂的功能设计提供了理论依据.Biocompatible and biodegradable sodium alginate(SA)was used to stabilize Au nanoclusters(NCs)in this paper.Combined with the chemical inertness of Au,SA-AuNCs of(4.2±0.9)nm in diameter exhibited extremely low cytotoxicity.After administrated into mice,SA could delay the renal clearance of SA-AuNCs and prolong the half-life to(8.2±0.2)h in blood circulation.Thus the tumor uptake rate was increased to 10.4%ID/g.When tumor area contained high concentration of calcium ions,the tumor uptake rate could be further improved to 14.5%ID/g due to cross-link between Ca2+and SA.The SA-AuNCs were mainly excreted through renal clearance,which only involved minor,but recoverable interference to the renal function.This indicates good biosafety of SA-AuNCs.This work can solves the contradiction between the renal clearance and tumor uptake of nanoclusters by using functional of ligands,which provides theoretical guidance for other high-performance diagnostic and therapeutic nanomaterials.

关 键 词：纳米簇 肾脏清除 生物安全性 肿瘤摄取 电子计算机断层扫描成像 

分 类 号：O636[理学—高分子化学] O648[理学—化学]