稀土上转换纳米粒子掺杂口腔复合树脂材料的近红外光固化  

Near-infrared Light Curing of Dental Resin Composite Doped with Rare Earth Upconversion Nanoparticles

作　　者：乐鑫 贾庭芳 陈瑶[1,3] 周远柱 曲佳菲 李聪 申静 YUE Xin;JIA Tingfang;CHEN Yao;ZHOU Yuanzhu;QU Jiafei;LI Cong;SHEN Jing(International VIP Dental Clinic Tianjin Stomatological Hospital,School of Medicine,Nankai University,Tianjin 300041,China;School and Hospital of Stomatology,Tianjin Medical University,Tianjin,300071,China;Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction,Tianjin 300041,China)

机构地区：[1]南开大学医学院,天津市口腔医院国际诊疗中心,天津300041 [2]天津医科大学口腔医学院,天津300071 [3]天津市口腔功能重建重点实验室,天津300041

出　　处：《高等学校化学学报》2025年第1期188-195,共8页Chemical Journal of Chinese Universities

基　　金：天津市卫生健康科技项目(批准号:TJWJ2023MS033,TJWJ2023XK0260);国家自然科学基金(批准号:82101032);天津市医学重点学科(专科)建设项目(批准号:TJYXZDXK-078D);天津市卫生健康委员会中医中西医结合科研课题(批准号:2023179)资助.

摘　　要：为了提高现有复合树脂材料在近红外光下的固化效果和生物相容性,合成了一种无细胞毒性的稀土上转换纳米粒子(REUCNPs)掺杂的口腔复合树脂材料.荧光光谱分析结果表明,该REUCNPs在808nm近红外光激发下发射出450~475nm的可见光,可被光引发剂樟脑醌(CQ)有效吸收.研究结果表明,将该REUCNPs掺入树脂基质中,可增强树脂单体的固化性能、机械性能和单体转化率,并具备良好的生物相容性.当该口腔复合树脂材料中含有1%(质量分数)樟脑醌/甲基丙烯酸二甲氨基乙酯(CQ/DMAEMA)和4%(质量分数)REUCNPs时,在808nm近红外光的照射下实现了最佳的固化效果,并可掺杂质量分数为40%的改性SiO_(2)无机填料以获得较好的机械强度.REUCNPs掺杂的口腔复合树脂材料在近红外光照射下具有较好的固化效果和生物相容性,为龋病治疗提供了一个有前途的替代方案.To enhance the curing performance and biocompatibility of current resin composites under near-infrared light,a novel dental resin composite incorporating non-cytotoxic rare earth upconversion nanoparticles(RE UCNPs)has been developed.Fluorescence spectrum studies reveal that these RE UCNPs emit visible light at 450—475 nm when stimulated by an 808 nm near-infrared laser,corresponding to the excitation wavelength of the photoinitiator camphorquinone(CQ).The integration of RE UCNPs into the resin matrix enhances monomer curing,mechanical properties,monomer conversion rate,and biocompatibility.With optimal concentrations of 1%(mass fraction)camphorquinone/2-(dimethylamino)ethyl methacrylate(CQ/DMAEMA)and 4%(mass fraction)RE UCNPs,the composite achieves maximum curing efficacy under 808 nm irradiation.Additionally,the composite can incorporate up to 40% modified SiO_(2) inorganic filler to achieve improved mechanical strength.The dental resin composites incor⁃porating RE UCNPs improved the curing effect and biocompatibility of current resin composites under near-infrared light,presenting a promising alternative for dental caries treatment.

关 键 词：龋齿 上转换纳米粒子 口腔复合树脂 

分 类 号：O611[理学—无机化学]