负载阿奇霉素的聚多巴胺纳米粒子用于牙周炎治疗  

Azithromycin-loaded Polydopamine Nanoparticles for the Treatment of Periodontitis

作　　者：王璐[1] 叶强 王秀丽[1] 赵明璨 李毅[1] 侯宇川[2] WANG Lu;YE Qiang;WANG Xiuli;ZHAO Mingcan;LI Yi;HOU Yuchuan(Department of Pediatric Dentistry,Hospital of Stomatology,Jilin University,Changchun 130021;Department of Urinary,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学口腔医院儿童口腔科,长春130021 [2]吉林大学第一医院泌尿外科,长春130021

出　　处：《高等学校化学学报》2025年第1期226-233,共8页Chemical Journal of Chinese Universities

基　　金：吉林省财政厅医疗卫生人才建设项目(批准号:JCSZ2021893-30);中国博士后科学基金(批准号:2023M741344)资助.

摘　　要：利用二甲基咪唑与六水合硝酸锌之间的配位作用制备了正十二面体形貌的ZIF-8;再以ZIF-8为模板,多巴胺盐酸盐为原料,利用配位竞争诱导聚合法制备了中空结构的聚多巴胺纳米粒子(PDANPs);进一步以PDA NPs为载体负载药物,制备了负载阿奇霉素(AZM)的聚多巴胺纳米粒子(AZM@PDA NPs).研究结果表明,PDANPs的中空结构有助于阿奇霉素的大量负载,载药率高达20.2%.AZM@PDANPs的生物相容性高,对正常细胞的毒性极低,能够促进细胞中抗炎因子的表达.AZM@PDANPs实现的药物缓释能够有效治疗牙周炎,对抗牙槽嵴吸收,并且在体内的生物安全性良好,应用前景广阔.By the coordination between dimethylimidazole and ZnNO3·6H2O,the dodecahedral ZIF-8 were prepared first.Using ZIF-8 as template and dopamine hydrochloride as raw material,polydopamine nanoparticles(PDA NPs)with hollow structure were then prepared by chelation competition induced polymerization(CCIP)method.Further⁃more,by using PDA NPs as drug carrier,azithromycin loaded PDA NPs(AZM@PDA NPs)were finally prepared.The hollow structure of PDA NPs contributed to high azithromycin loading with a drug loading rate of up to 20.2%.AZM@PDA NPs have high biocompatibility and low cytotoxicity,and can promote the expression of antiinflammatory cytokines in cells.The sustained release of azithromycin achieved by AZM@PDA NPs can effectively treat periodontitis and resist alveolar ridge resorption,with good biosafety in vivo and broad application prospects.

关 键 词：阿奇霉素 聚多巴胺 载药 药物缓释 牙周炎治疗 

分 类 号：O631[理学—高分子化学]