N-卤胺聚合物表面修饰金纳米粒子的抗菌性能  

Antibacterial Properties of N-halamine Modified Gold Nanoparticles

作　　者：萨仁格日乐 梁靖 关少钰 常宇佳 张佳博 梁楠[2] 亢静 董阿力德尔图[1] SAREN Gerile;LIANG Jing;GUAN Shaoyu;CHANG Yujia;ZHANG Jiabo;LIANG Nan;KANG Jing;DONG Alideertu(College of Chemistry and Chemical Engineering,Inner Mongolia University,Engineering Research Center of Dairy Quality and Safety Control Technology,Ministry of Education,Hohhot 010021,China;Thyroid Surgery Department of Jilin University Sino Japanese Friendship Hospital,Changchun 130000,China)

机构地区：[1]内蒙古大学化学化工学院,教育部乳品质量安全控制技术工程研究中心,呼和浩特010021 [2]吉林大学中日联谊医院甲状腺外科,长春130000

出　　处：《高等学校化学学报》2025年第1期252-262,共11页Chemical Journal of Chinese Universities

基　　金：内蒙古自治区自然科学基金(批准号:2023QN02011);内蒙古自治区高等学校科学技术研究项目(批准号:NJZZ23091)资助。

摘　　要：由致病菌引发的各类疾病对人类生命健康造成持续威胁.致病菌的耐药性逐渐增强,导致抗生素效力逐步减弱.然而,目前多数纳米材料主要以单一组分抗菌为主,其单一性和片面性阻碍了对微生物污染的全面预防和高效控制.为了预防和遏制细菌耐药性的滋生与蔓延,本文提出了一种有效复合多种抗菌材料构建多元抗菌体系的方法,以实现多组分协同杀菌效果.将高效杀菌的N-卤胺聚合物与具备光热效应(PTT)的金纳米粒子(AuNP)相结合,开发出一种新型的AuNP@pAMPS-Cl-b-PEG纳米抗菌材料.该材料可充分发挥光热与化学抗菌机制的协同作用,更有效地抑制细菌,降低了抗生素耐药性的发生.该方法为联合抗菌治疗提供了新的策略.The various types of diseases caused by pathogenic bacteria pose a constant threat to human life and health.The drug resistance of pathogenic bacteria is gradually increasing,which leads to a gradual decrease in the effectiveness of antibiotics.However,most of the current nanomaterials are mainly single-component antibacterials,whose singularity and one-sidedness hinder the comprehensive prevention and efficient control of microbial contamination.In order to prevent and curb the growth and spread of bacterial resistance,this work proposed the strategy of effectively compounding multiple antibacterial materials and constructing a multifaceted antibacterial system to achieve a multi-component synergistic bactericidal effect.In the study,a novel Au NP@pAMPS-Cl-b-PEG nano-antibacterial material was successfully developed by combining N-halamine polymer,which is an efficient bactericidal polymer,with gold nanoparticles(Au NP)possessing photothermal effect(PTT).The antibacterial material aims to fully utilize the synergistic effect of photothermal and chemical antibacterial mechanisms to effectively inhibit bacteria and reduce the occurrence of antibiotic resistance.This research provides a new strategy for combined antibacterial therapy,which is of great theoretical significance and reference value for promoting the development and application of novel antibacterial drugs.

关 键 词：抗菌材料 N-卤胺 金纳米粒子 光热效应 活性氯 

分 类 号：O614[理学—无机化学]