亚麻醉剂量艾司氯胺酮在腹腔镜全子宫切除术中的应用效果  

Application Effect of Subanesthetic Dose Esketamine in Laparoscopic Total Hysterectomy

作　　者：韦英艳 许培俊 WEI Yingyan;XU Peijun(Qinzhou First People's Hospital,Qinzhou 535000,China;不详)

机构地区：[1]钦州市第一人民医院,广西钦州535000

出　　处：《中外医学研究》2025年第2期116-119,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析亚麻醉剂量艾司氯胺酮在腹腔镜全子宫切除术中的应用效果。方法:选取2023年2月—2024年2月钦州市第一人民医院收治的80例腹腔镜全子宫切除术患者作为观察对象。根据数字列表法随机将其分为对照组与观察组,各40例。两组均给予全身麻醉,于手术结束前30 min时,观察组给予亚麻醉剂量艾司氯胺酮,对照组给予等剂量安慰剂生理盐水。记录两组镇痛药物用量、疼痛程度、苏醒指标及不良反应。结果:术后2~24 h,观察组视觉模拟评分法(visual analogue scale,VAS)评分及布托啡诺总消耗量均低于对照组,差异有统计学意义(P<0.05)。两组呼吸恢复时间、拔管时间、睁眼时间比较,差异无统计学意义(P>0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:腹腔镜全子宫切除术中加用亚麻醉剂量艾司氯胺酮辅助可显著减少患者术后的镇痛药物使用剂量,减轻疼痛,且不影响患者的麻醉恢复、麻醉效果,有助于提升患者术后的舒适性。Objective:To analyze the application effect of subanesthetic dose Esketamine in laparoscopic total hysterectomy.Method:A total of 80 patients with laparoscopic total hysterectomy treated in Qinzhou First People's Hospital from February 2023 to February 2024 were selected as the observation objects.They were randomly divided into control group and observation group,with 40 cases in each group.Both groups were given general anesthesia.At 30 minutes before the end of the surgery,the observation group was given subanesthetic dose of Esketamine and the control group was given placebo of Normal Saline.The dosage of analgesic drugs,pain degree,recovery index and adverse reactions were recorded in the two groups.Result:From 2 to 24 h after surgery,the visual analogue scale(VAS)score and total Butorphanol consumption in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in respiratory recovery time,extubation time,eye opening time between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The addition of subanesthetic dose of Esketamine during laparoscopic total hysterectomy can significantly reduce postoperative analgesic drug dosage,relieve pain,and do not affect the recovery of anesthesia and anesthesia efficiency of patients,and help improve the postoperative comfort of patients.

关 键 词：腹腔镜全子宫切除术 艾司氯胺酮 亚麻醉剂量 镇痛 

分 类 号：R614[医药卫生—麻醉学]