阿立哌唑治疗精神分裂症疗效与安全性研究  

Study on the efficacy and safety of aripiprazole in the treatment of schizophrenia

作　　者：熊永志 骆翠萍 Xiong Yongzhi;Luo Cuiping(Jiangxi Mental Hospital,Jiangxi 330000)

机构地区：[1]江西省精神病院,江西330000

出　　处：《天津药学》2024年第6期69-72,共4页Tianjin Pharmacy

摘　　要：目的:探讨阿立哌唑对精神分裂症患者精神症状、神经相关因子及认知功能的疗效与安全性。方法:选取2022年1月—2024年3月期间本院收治的精神分裂症患者96例,分组方法为随机数表法,分为对照组(48例)和研究组(48例)。对照组口服利培酮,起始1 mg/d,1~2周内增至6 mg/d,1次/d;研究组口服阿立哌唑,起始5 mg/d,2~3周内增至30 mg/d,1次/d。两组均治疗2个月,期间可视不良反应给予β阻滞剂及抗胆碱药。比较两组精神症状、神经相关因子、认知功能、疗效与安全性。结果:干预前两组PANSS评分和MCCB评分比较无统计学差异(P>0.05);两组干预1周与干预前比较PANSS评分和MCCB评分均下降(P<0.05);两组干预1个月与干预1周比较PANSS评分和MCCB评分均下降(P<0.05);干预后1周和干预后1个月研究组的PANSS评分和MCCB评分相较于对照组均更低(P<0.05)。干预前两组BDNF、NGF及NT-3水平比较无统计学差异(P>0.05);与干预前比较,两组干预后1个月血清BDNF、NGF及NT-3水平升高(P<0.05);且与对照组比较,研究组干预后1个月血清BDNF、NGF及NT-3水平更高(P<0.05)。与对照组比较,研究组的治疗总有效率更高(95.83%vs 75.00%,P<0.05)。研究组与对照组的不良反应发生率比较无统计学差异(6.25%vs 10.42%,P﹥0.05)。结论:阿立哌唑相较于利培酮治疗精神分裂症患者疗效更好,可有效改善患者精神症状和认知功能,上调血清BDNF、NGF和NT-3水平,安全性高。Objective:To explore the efficacy and safety of aripiprazole for psychotic symptoms,nerve-related factors,and cognitive function in patients with schizophrenia.Methods:Ninety-six schizophrenia patients admitted to our hospital between January 2022 and March 2024 were selected and divided into a control group(48 patients)and a research group(48 cases)using the random number table method.The control group was administered oral risperidone,with an initial dose of 1 mg/day,which was increased to 6 mg/d within 1~2 weeks,once a day.The research group was administered oral aripiprazole,with an initial dose of 5 mg/day,which was increased to 30 mg/d within 2~3 weeks,once a day.Both groups were treated for two months,and beta-blockers and anticholinergic drugs were administered during this period based on adverse reactions.Psychotic symptoms,nerve-related factors,cognitive function,efficacy,and safety of the two groups were compared.Results:PANSS and MCCB scores did not differ significantly between the two groups before the intervention(P>0.05).The PANSS and MCCB scores of both groups decreased one week after the intervention compared with those before the intervention(P<0.05).The PANSS and MCCB scores of both groups decreased one month after the intervention compared with those at one week after the intervention(P<0.05).The PANSS and MCCB scores of the research group were lower than those of the control group one week and one month after the intervention(P<0.05).There were no significant differences in the levels of BDNF,NGF,and NT-3 between the two groups before the intervention(P>0.05).Compared with those before the intervention,the serum levels of BDNF,NGF,and NT-3 in both groups increased one month after the intervention(P<0.05).Compared with the control group,the serum levels of BDNF,NGF,and NT-3 in the research group were higher one month after the intervention(P<0.05).Compared with the control group,the research group had a higher total effective treatment rate(95.83%vs 75.00%,P<0.05).There was no significant diff

关 键 词：精神分裂症 利培酮 阿立哌唑 精神症状 认知功能 

分 类 号：R971.41[医药卫生—药品]