健脾生血片联合促红素治疗肾性贫血的疗效及对血清铁参数和炎症因子水平的影响  

Effect of Jianpi Shengxue tablets combined with erythropoietin on treating renal anemia and its impact on serum iron parameters and inflammatory factor levels

作　　者：刘米荣 Liu Mirong(Shangrao Traditional Chinese Medicine Hospital,Jiangxi334000)

机构地区：[1]上饶市中医院,江西334000

出　　处：《天津药学》2024年第6期73-76,共4页Tianjin Pharmacy

摘　　要：目的:探讨健脾生血片联合促红素治疗肾性贫血的疗效及对血清铁参数和炎症因子水平的影响。方法:选取2021年1月—2023年12月本院收治的100例肾性贫血患者。依据随机数字表法将其分为观察组和对照组,每组50例。两组患者均接受常规治疗维持患者基本健康状态、缓解疾病症状以及预防并发症。对照组给予促红素,观察组在对照组基础上给予健脾生血片。比较两组患者疗效、中医证候积分、血清铁参数及炎症因子水平。结果:观察组总有效率(88.00%)显著高于对照组(68.00%),两组比较差异有统计学意义(P<0.05)。治疗前两组中医证候积分比较无显著差异(P>0.05);治疗后两组中医证候积分均显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05)。治疗前两组患者血清铁参数比较均无显著差异(P>0.05);治疗后两组血清铁蛋白、转铁蛋白、总铁结合力及转铁蛋白饱和度均显著高于治疗前(P<0.05),且观察组显著高于对照组(P<0.05)。治疗前两组患者炎症因子水平比较均无显著差异(P>0.05);治疗后两组C反应蛋白及血清淀粉样蛋白A显著低于治疗前(P<0.05),且观察组显著低于对照组(P<0.05)。结论:健脾生血片联合促红素治疗RA具有显著优势,能够提高治疗效果,改善中医证候,调节血清铁参数和降低炎症因子水平。Objective:To investigate the efficacy of Jianpi Shengxue tablets combined with erythropoietin for the treatment of renal anemia and their impact on serum iron and inflammatory factor levels.Methods:One hundred patients with renal anemia admitted to our hospital between January 2021 and December 2023 were selected.According to the random number table method,patients were divided into observation and control groups,with 50 patients in each group.Both groups of patients received conventional treatments to maintain their basic health status,relieve disease symptoms,and prevent complications.The control group was administered erythropoietin,and the observation group was administered Jianpi Shengxue tablets.Efficacy,traditional Chinese medicine(TCM)syndrome scores,serum iron parameters,and inflammatory factor levels in both groups were compared.Results:The total effective rate in the observation group(88.00%)was significantly higher than that in the control group(68.00%)(P<0.05).Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05).After treatment,the TCM syndrome scores of both groups were significantly lower than before treatment(P<0.05),and the scores of the observation group were significantly lower than those of the control group(P<0.05).Before treatment,there was no significant difference in the serum iron parameters between the two groups(P>0.05).After treatment,serum ferritin,transferrin,total iron-binding capacity,and transferrin saturation of both groups were significantly higher than before treatment(P<0.05),and those of the observation group were significantly higher than those of the group(P<0.05).Before treatment,there was no significant difference in the levels of inflammatory factors between the two groups of patients(P>0.05).After treatment,C-reactive protein(CRP)and serum amyloid A(SAA)levels in both groups were significantly lower than before treatment(P<0.05),and those in the observation group were significantly lower than those in the control gro

关 键 词：健脾生血片 促红素 肾性贫血 疗效 血清铁参数 炎性因子 

分 类 号：R973.3[医药卫生—药品]