司库奇尤单抗治疗难治性泛发性脓疱型银屑病一例  

A case of treatment with secukinumab for refractory generalized pustular psoriasis

作　　者：吴仙梅 方美珍 童中胜[2] WU Xianmei;FANG Meizhen;TONG Zhongsheng(School of Medicine,Jianghan University,Wuhan 430056;Dermatology Department,Wuhan No.1 Hospital,Wuhan 430022,China)

机构地区：[1]江汉大学医学部,湖北武汉430056 [2]武汉市第一医院皮肤科,湖北武汉430022

出　　处：《临床医学研究与实践》2025年第1期18-21,共4页Clinical Research and Practice

摘　　要：泛发性脓疱型银屑病(GPP)是一种少见而严重的银屑病亚型,可在数周内泛发至全身,常发生在有斑块型银屑病病史的基础上。传统治疗方案包括使用阿维A、环孢素、糖皮质激素等。司库奇尤单抗目前在国内并无GPP的适应证,通过该药治疗的病例并不多见。现报道1例无斑块型银屑病病史、被误诊为重症药疹的难治性GPP、用白细胞介素-17A(IL-17A)抑制剂司库奇尤单抗治疗后效果明显的患者,旨在为类似病例诊断、鉴别诊断及治疗提供思路。Generalized pustular psoriasis(GPP)is a rare and severe subtype of psoriasis,which can spread to the whole body in a few weeks and often occurs on the basis of a history of plaque psoriasis.Traditional treatment options include the use of avitamin A,cyclosporine,glucocorticoids,etc.Secukinumab currently has no indication for GPP in China,and cases treated with this drug are rare.This paper reports a case of patients with refractory GPP without a history of plaque psoriasis and misdiagnosed as severe drug eruption,and the effect was obvious after treated with interleukin-17A(IL-17A)inhibitor secukinumab.The aim is to provide ideas for the diagnosis,differential diagnosis,and treatment of similar cases.

关 键 词：泛发性脓疱型银屑病 司库奇尤单抗 重症药疹 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]