广东省7个城市气态污染物与心血管疾病入院人数、住院费用和住院天数的关系  

Study on the association between gaseous pollutants and cardiovascular disease hospitalization,hospitaliza-tion costs,and hospitalization days in seven cities of Guangdong province

作　　者：陈星宇 肖颖 林华亮 Lawrence Lam CHEN Xingyu;XIAO Ying;LIN Hualiang;Lawrence Lam(School of Medicine,Macao University of Science and Technology,Macao 999078,Macao,China;不详)

机构地区：[1]澳门科技大学医学院,中国澳门999078 [2]中山大学公共卫生学院,广东广州510000

出　　处：《实用医学杂志》2025年第2期278-287,共10页The Journal of Practical Medicine

基　　金：国家重点研发计划项目(编号:2022YFC2305305)。

摘　　要：目的 探索气态污染物(SO_(2)、NO_(2)、CO、O_(3))对广东省7个城市心血管疾病入院人数、住院费用和住院时间的影响。方法 纳入2017年1月至2019年12月广东省7个城市的2 010 905例心血管疾病患者为研究对象。从广东省电子医疗信息系统中获取心血管疾病住院患者人口学特征和住院情况,并在中国高分辨率高质量近地表空气污染物数据集提取SO_(2)、NO_(2)、CO和O_(3)每日暴露浓度。采用多步骤时间序列分析方法估计了气态污染物对广东省7个城市心血管系统疾病的影响。结果 lag0时(入院当天)SO_(2)、NO_(2)、CO浓度与心血管疾病入院人数、住院费用、住院时长均呈正相关,且NO_(2)影响最大,另外NO_(2)、CO的负面作用存在滞后效应,而O_(3)浓度在lag0-7的时间窗内均与心血管疾病入院人数、住院费用、住院时长呈负相关。结论 SO_(2)、NO_(2)、CO短期暴露可能与增加心血管疾病患者的疾病负担有一定相关性,且由于NO_(2)较大的负面作用,仍然建议加强NO_(2)的监控。但考虑本研究为回顾性研究,需要进一步开展深入研究。Objective To investigate the impact of gaseous pollutants(SO_(2),NO_(2),CO,O_(3))on hospital admissions,hospitalization costs,and length of stay for cardiovascular diseases in seven cities of Guangdong Province.Methods A total of 2,010,905 patients with cardiovascular diseases from seven cities in Guangdong Province between January 2017 and December 2019 were included.Demographic characteristics and hospitalization data for cardiovascular disease inpatients were obtained from the Guangdong Province Electronic Healthcare Information System.Daily exposure concentrations of SO_(2),NO_(2),CO and O_(3) were extracted from the China High‐Air‐Pollution Dataset.The impact of air pollutants on cardiovascular diseases in the seven cities of Guangdong Province was estimated using a multi‐step time‐series analysis.Results SO_(2),NO_(2),and CO concentrations on the day of admission(lag0)were positively associated with the risk of cardiovascular admissions,hospitalization costs,and length of stay,with NO_(2) exhibiting the strongest effect.Additionally,there was a lagged negative impact of NO_(2) and CO,while O_(3) concentrations were inversely correlated with the number of cardiovascular admissions,hospitalization costs,and length of stay over the lag0‐7 period.Conclusions Short‐term exposures to SO_(2),NO_(2),and CO are likely positively associated with the disease burden in CVD patients.Furthermore,given the more substantial adverse effects of NO_(2),enhanced monitoring of NO_(2) remains essential.However,as this study is retrospective,additional research is warranted.

关 键 词：空气污染 气态污染物 心血管疾病 疾病负担 

分 类 号：R122.7[医药卫生—环境卫生学]