注射用炎琥宁(冻干)联合利巴韦林治疗病毒性肺炎的临床研究  

Clinical study on Potassium Sodium Pehydroandroandrographolide Succinate for injection(lyophilized)combined with ribavirin in treatment of viral pneumonia

作　　者：茆龙欢 沈燕 钮志林 赵刚 高胜利 MAO Longhuan;SHEN Yan;NIU Zhilin;ZHAO Gang;GAO Shengli(Department of Infection,Suzhou Ninth People's Hospital,Suzhou 215000,China)

机构地区：[1]苏州市第九人民医院感染科,江苏苏州215000

出　　处：《现代药物与临床》2024年第12期3115-3118,共4页Drugs & Clinic

基　　金：苏州市吴江区科教兴卫项目(WWK201608)。

摘　　要：目的探讨注射用炎琥宁(冻干)联合利巴韦林注射液治疗病毒性肺炎的效果。方法选取2022年5月—2023年5月苏州市第九人民医院收治的80例病毒性肺炎患者,以随机数字表法分为对照组和治疗组,每组各40例。对照组患者静脉滴注利巴韦林注射液,每次500 mg加于500 mL 5%葡萄糖注射液中,2次/d。治疗组在对照组基础上静脉滴注注射用炎琥宁(冻干),每次400 mg加于250 mL 5%葡萄糖注射液中,1次/d。两组连续治疗5 d。比较两组的临床疗效、临床症状缓解时间、炎症指标。结果治疗后,治疗组的总有效率(97.50%)比对照组的总有效率(80.00%)更高(P<0.05);治疗后,治疗组发热、咽痛、咳嗽缓解时间均短于对照组(P<0.05);治疗后,两组患者血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)水平均降低(P<0.05),治疗组患者血清IL-6、TNF-α、CRP水平与对照组相比更低(P<0.05)。结论注射用炎琥宁(冻干)联合利巴韦林注射液治疗病毒性肺炎具有较好疗效,能有效地缓解临床症状,减轻机体炎症反应。Objective To explore the therapeutic effect of Potassium Sodium Pehydroandroandrographolide Succinate for injection(lyophilized)combined with Ribavirin Injection in treatment of viral pneumonia Methods 80 Patients with viral pneumonia admitted to Suzhou Ninth People's Hospital from May 2022 to May 2023 were divided into a control group(n=40 cases)and a treatment group(n=40 cases)using a random number table method.The control group received intravenous infusion of Ribavirin Injection,with each dose of 500 mg added to 500 mL 5%glucose injection,twice daily.On the basis of control group,the treatment group received Potassium Sodium Pehydroandroandrographolide Succinate for injection(lyophilized),with each dose of 400 mg added to 250 mL 5%glucose injection once daily.Both groups were treated for 5 d.The clinical efficacy,symptom relief times,and inflammatory index levels between the two groups were compared.Results After treatment,the total effective rate of patients in the treatment group(97.50%)was higher than 80.00%in the control group(P<0.05).After treatment,the improvement time of fever,sore throat,and cough in the treatment group was shorter than those of the control group(P<0.05).After treatment,the levels of serum IL-6,TNF-α,and CRP in the two groups were lower than those before treatment(P<0.05),and the levels of serum IL-6,TNF-α,and CRP in the treatment group were lower than those in the control group(P<0.05).Conclusion Potassium Sodium Pehydroandroandrographolide Succinate for injection(lyophilized)combined with Ribavirin Injection has a definite therapeutic effect on viral pneumonia,which can effectively alleviate clinical symptoms and inflammatory reactions.

关 键 词：注射用炎琥宁(冻干) 利巴韦林注射液 病毒性肺炎 发热缓解时间 咽痛缓解时间 咳嗽缓解时间 白细胞介素-6 肿瘤坏死因子-α C反应蛋白 

分 类 号：R974[医药卫生—药品]