定量磁化率成像在评估直肠癌病理T分期、脉管和神经侵犯中的初步应用  

Preliminary application of quantitative susceptibility mapping in evaluating pathological T staging,vascular and nerve invasion in rectal cancer

作　　者：张海妮 刘忠啸 孙小伶 李可可 孟闫凯 庄银苹 吴鹏 徐凯 ZHANG Haini;LIU Zhongxiao;SUN Xiaoling;LI Keke;MENG Yankai;ZHUANG Yinping;WU Peng;XU Kai(Department of Radiology,The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221002,China;School of Medical Imaging,Xuzhou Medical University;Jiangsu Medical Imaging and Digital Medicine Engineering Research Center;Philips Healthcare;School of Medical Technology,Xuzhou Medical University)

机构地区：[1]徐州医科大学附属医院影像科,徐州221002 [2]徐州医科大学医学影像学院 [3]江苏省医学影像与数字医学工程研究中心 [4]飞利浦医疗 [5]徐州医科大学医学技术学院

出　　处：《国际医学放射学杂志》2025年第1期15-19,共5页International Journal of Medical Radiology

基　　金：江苏省中医药科技发展计划项目(MS2021100);江苏省卫生健康委老年健康科研项目(LKM2022018)。

摘　　要：目的探讨定量磁化率成像(QSM)技术在评估直肠癌病理T分期(pT)、脉管和神经侵犯中的应用价值。方法回顾性分析经病理证实并于术前行直肠QSM检查的29例直肠癌病人资料,根据病理结果中的pT分期将病人分为pT1-2期组(13例)和pT3-4期组(16例),根据有无脉管侵犯分为脉管侵犯阳性组(9例)和阴性组(20例),根据有无神经侵犯分为神经侵犯阳性组(3例)和阴性组(26例)。在MATLAB version 2018b平台上对QSM影像进行处理,将得到的QSM加权影像导入FireVoxel build 394D软件(https://firevoxel.org/)进行分割,并由软件自动生成肿瘤组织的磁化率直方图参数。采用Mann-Whitney U检验比较各组间的组织磁化率值。结果pT3-4期第60、70、80、90百分位的组织磁化率值高于pT1-2期组(均P<0.05)。脉管侵犯阳性组第60、70、80、90百分位的组织磁化率值高于脉管侵犯阴性组(均P<0.05)。神经侵犯阳性组、阴性组的组织磁化率值差异均无统计学意义(均P>0.05)。结论QSM技术可以应用于直肠癌研究,基于QSM技术的定量磁化率值可以反映直肠癌pT分期、脉管和神经侵犯的差异。Objective To explore the value of quantitative susceptibility mapping(QSM)in assessing pathological T staging(pT),vascular invasion,and neural invasion in rectal cancer.Methods Data from 29 rectal cancer patients confirmed by pathology and undergoing preoperative QSM examination were retrospectively analyzed.According to pathological results,patients were divided into pT1-2(n=13)and pT3-4(n=16)groups based on pT staging,vascular invasion-positive(n=9)and-negative(n=20)groups,and neural invasion-positive(n=3)and-negative(n=26)groups.QSM images were processed on the MATLAB version 2018b platform,and the QSM-weighted images were imported into FireVoxel build 394D software(https://firevoxel.org/)for segmentation.Histogram parameters of tumor susceptibility were automatically generated by the software.Mann-Whitney U tests were used to compare tissue susceptibility values between groups.Results The tissue susceptibility values at the 60th,70th,80th,and 90th percentiles were significantly higher in the pT3-4 group compared to the pT1-2 group(all P<0.05).Similarly,vascular invasion-positive groups had significantly higher susceptibility values at these percentiles than vascular invasion-negative groups(all P<0.05).No significant differences in susceptibility values were observed between neural invasion-positive and-negative groups(all P>0.05).Conclusions QSM technology can be applied to rectal cancer research.Quantitative susceptibility values derived from QSM can reflect differences in rectal cancer pT staging,vascular invasion,and neural invasion.

关 键 词：直肠癌 磁共振成像 定量磁化率成像 直方图分析 

分 类 号：R445.2[医药卫生—影像医学与核医学]