注射用甲泼尼龙琥珀酸钠在儿童肺炎支原体致大叶性肺炎治疗中的疗效分析  

Efficacy Analysis of Sodium Methylprednisolone Succinate Injection in the Treatment of Mycoplasma Pneumonia-Induced Lobular Pneumonia in Children

作　　者：李艳霞[1] 白晨艳 赵淑丽 LI Yanxia;BAI Chenyuan;ZHAO Shui(Department of Pediatrics,Suixian People's Hospital,Shangqiu Henan 476900,China)

机构地区：[1]睢县人民医院儿科,河南商丘476900

出　　处：《临床研究》2025年第2期50-52,共3页Clinical Research

摘　　要：目的探讨注射用甲泼尼龙琥珀酸钠在儿童肺炎支原体致大叶性肺炎治疗中的临床疗效。方法本研究采用回顾分析法,选取睢县人民医院儿科收入的96例因肺炎支原体感染导致大叶性肺炎的患儿进行研究,根据治疗方法不同,分为对照组与研究组,均48例。2022年5月至2023年5月收入患儿为对照组,使用阿奇霉素治疗;2023年6月至2024年5月收入患儿为研究组,在对照组治疗方案基础上增加甲泼尼龙琥珀酸钠,将两组患儿临床治疗效果、实验室检查指标(C反应蛋白、降钙素原)、症状缓解时间(发热、气喘、咳嗽、肺啰音消失)、不良反应发生情况(腹泻、恶心呕吐、食欲不振)进行比较。结果研究组患儿的治疗有效率(97.92%)高于对照组(85.42%),差异具有统计学意义(P<0.05)。治疗前,两组患儿C反应蛋白、降钙素原比较,差异无统计学意义(P>0.05);治疗后,研究组患儿C反应蛋白、降钙素原低于对照组患儿,差异具有统计学意义(P<0.05)。研究组患儿症状缓解时间短于对照组患儿,差异具有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在治疗儿童肺炎支原体引起的大叶性肺炎时,甲泼尼龙琥珀酸钠具有良好疗效,能够缩短症状持续时间,降低炎症水平,且不良反应较少,值得临床应用。Objective To explore the clinical efficacy of sodium methylprednisolone succinate injection in the treatment of lobar pneumonia in children caused by Mycoplasma pneumoniae infection.Methods This study utilized a retrospective analysis of 96 children admitted to the pediatrics department of Suixian People's Hospital,diagnosed with lobar pneumonia due to Mycoplasma pneumoniae infection.According to different treatment methods,the children were divided into a control group and a study group,with 48 cases in each group.Patients admitted from May 2022 to May 2023 constituted the control group,which received azithromycin treatment;patients admitted from June 2023 to May 2024 comprised the study group,which received sodium methylprednisolone succinate in addition to the treatment plan of the control group.Clinical treatment effects,laboratory examination indicators(C-reactive protein,procalcitonin),symptom relief times(fever,dyspnea,cough,and resolution of lung rales),and the occurrence of adverse reactions(diarrhea,nausea,vomiting,and loss of appetite)were compared between the two groups.Results The treatment effective rate in the study group(97.92%)was significantly higher than that in the control group(85.42%),with statistically significant differences(P<0.05).Before treatment,there were no significant differences in C-reactive protein and procalcitonin levels between the two groups(P>0.05);however,after treatment,the study group's levels of C-reactive protein and procalcitonin were lower than those of the control group,showing statistically significant differences(P<0.05).The symptom relief time in the study group was shorter than that in the control group,with significant differences(P<0.05).There were no statistically significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sodium methylprednisolone succinate injection demonstrates good efficacy in treating lobar pneumonia caused by Mycoplasma pneumoniae in children,significantly shortening the duration of symptoms an

关 键 词：甲泼尼龙琥珀酸钠 肺炎支原体 大叶性肺炎 

分 类 号：R725.6[医药卫生—儿科]