cTnI、CTGF、AngⅡ和miR-21在老年性慢性心力衰竭肺部感染中的诊断价值  

Diagnostic Value of cTnI,CTGF,AngⅡ,and miR-21 in Pulmonary Infection in Elderly Patients with Chronic Heart Failure

作　　者：冯雪 时芳芳 FENG Xue;SHI Fangfang(Department of Laboratory Medicine,Zhengzhou Jinsui District General Hospital,Zhengzhou Henan 450000,China)

机构地区：[1]郑州市金水区总医院检验科,河南郑州450000

出　　处：《临床研究》2025年第2期141-144,共4页Clinical Research

摘　　要：目的探讨心肌肌钙蛋白I(cTnI)、结缔组织生长因子(CTGF)、血管紧张素Ⅱ(AngⅡ)和微小核糖核酸-21(miR-21)在老年性慢性心力衰竭肺部感染中的诊断价值。方法选取郑州市金水区总医院2022年1月至2023年8月收治的70例老年性慢性心衰肺部感染患者作为合并感染组,同期70例老年单纯心衰患者作为单纯心衰组,以及同期70例老年健康体检者作为对照组。比较三组研究对象临床指标及cTnI、CTGF、AngⅡ、miR-21水平,比较合并感染组不同心功能分级cTnI、CTGF、AngⅡ、miR-21水平,分析老年性慢性心衰肺部感染与cTnI、CTGF、AngⅡ、miR-21相关性。结果合并感染组血清cTnI、CTGF、AngⅡ、miR-21均高于单纯心衰组和对照组,单纯心衰组高于对照组,差异有统计学意义(P<0.05);合并感染组心功能Ⅳ级患者血清cTnI、CTGF、AngⅡ、miR-21高于Ⅲ级和Ⅱ级,Ⅲ级高于Ⅱ级,差异有统计学意义(P<0.05);血清cTnI、CTGF、AngⅡ、miR-21均为老年性慢性心衰肺部感染的独立危险因素(P<0.05);Pearson相关性分析显示,老年性慢性心衰肺部感染与血清cTnI、CTGF、AngⅡ、miR-21水平呈正相关关系(r=0.566、0.543、0.555、0.582,P<0.05)。结论老年性慢性心力衰竭肺部感染患者多伴有血清cTnI、CTGF、AngⅡ、miR-21升高,cTnI、CTGF、AngⅡ、miR-21与老年性慢性心衰肺部感染存在相关性。Objective To explore the diagnostic value of cardiac troponin I(cTnI),connective tissue growth factor(CTGF),angiotensinⅡ(AngⅡ),and microRNA-21(miR-21)in pulmonary infections associated with chronic heart failure in elderly patients.Methods A total of 70 elderly patients with chronic heart failure and pulmonary infections were selected as the infection group from Zhengzhou Jinsui District General Hospital from January 2022 to August 2023.Additionally,70 elderly patients with simple chronic heart failure were included as the simple heart failure group,and 70 elderly healthy individuals served as the control group.Clinical indicators and serum levels of cTnI,CTGF,AngⅡ,and miR-21 were compared among the three groups.The levels of cTnI,CTGF,AngⅡ,and miR-21 were also compared based on different heart function grades in the infection group,and the correlation of these biomarkers with pulmonary infections in chronic heart failure was analyzed.Results The serum levels of cTnI,CTGF,AngⅡ,and miR-21 in the infection group were significantly higher than those in the simple heart failure and control groups,while the simple heart failure group had higher levels than the control group,with statistically significant differences(P<0.05).The serum levels of cTnI,CTGF,AngⅡ,and miR-21 in the infection group were higher in patients with New York Heart Association(NYHA)functional class IV compared to those with classesⅢandⅡ,and classⅢwas higher than classⅡ,with statistically significant differences(P<0.05).All four markers(cTnI,CTGF,AngⅡ,and miR-21)were identified as independent risk factors for pulmonary infection in elderly patients with chronic heart failure(P<0.05).Pearson correlation analysis revealed a positive correlation between pulmonary infection in chronic heart failure and serum levels of cTnI,CTGF,AngⅡ,and miR-21(r=0.566,0.543,0.555,0.582;P<0.05).Conclusion Elderly patients with chronic heart failure and pulmonary infections are frequently associated with elevated serum levels of cTnI,CTGF,AngⅡ,an

关 键 词：慢性心力衰竭 肺部感染 诊断价值 心肌肌钙蛋白I 结缔组织生长因子 

分 类 号：R541.6[医药卫生—心血管疾病]