Metallic nanoparticles for visual sensing:Design,mechanism,and application  

作　　者：Bharathi Natarajan Palanisamy Kannan Longhua Guo 

机构地区：[1]College of Biological,Chemical Sciences and Engineering,Jiaxing University,Jiaxing,314001,PR China [2]College of Medicine,Jiaxing University,Jiaxing,Zhejiang,314001,PR China

出　　处：《Chinese Journal of Structural Chemistry》2024年第9期60-76,共17页结构化学(英文)

基　　金：the National Natural Science Foundation of China(22074054);the Zhejiang Provincial High-level Talent Special Support Plan(2021R52044)for funding support.

摘　　要：Fascinating physico-chemical features of functionalized metallic nanoparticles(MNPs),which offer a high surface-to-volume ratio,biocompatibility,and flexible functionalities,are considered as potential building blocks in functionalized nano/biointerface,facilitating stable biosensing detection response towards various biological analytes.MNPs-based colorimetric biosensors have received enormous attention in chemistry,biology,and medicine owing to their simplicity,practicality,low-cost,high stability,and selectivity.Principally,the colori-metric biosensing is low-cost;it does not require advanced analytical instruments because the change in color of nanoparticle dispersion can be directly read out via the naked-eye,which is indeed used for on-field analysis and point-of-care(POC)analyses.Notably,MNPs such as gold,silver,iron oxide,and cerium oxide have been used for the simple and facile colorimetric detection of biologically important analytes via changes in various colors.In this review,the biosensing mechanism is based on the change in colors of MNPs toward the detection of clinically important biomolecules(glucose,ochratoxin A(OTA),etc.),deoxyribonucleic acid(DNA),prostate-specific an-tigen(PSA),α-fetoprotein(AFP),lipopolysaccharide(LPS),carcinoembryonic antigen(CEA),and proteins in various real samples.This promising discipline,at the interface of nanomaterials and biosciences,offers extensive projections for interdisciplinary researchers that comprise nanomaterial preparation,bio-element functionaliza-tion,and targeted detection in clinical diagnostics.The potential approaches for new colorimetric substrate design,important biosensing characteristics,challenges,and future opportunities for colorimetric biosensing strategies are also described.

关 键 词：Metallic nanoparticles Surface plasmon Biomolecules Real sample testing POINT-OF-CARE 

分 类 号：O641.4[理学—物理化学] O657.3[理学—化学]