基于薄膜晶体管的冠状病毒检测研究进展  

Research progress in coronavirus detection based on thin-film transistors

作　　者：涂建新 郝魁 孙乐 李爱军[1,2] TU Jianxin;HAO Kui;SUN Le;LI Aijun(School of Materials Science and Engineering,Shanghai University,Shanghai 200444,China;Shaoxing Institute of Technology,Shanghai University,Shaoxing 312000,Zhejiang,China)

机构地区：[1]上海大学材料科学与工程学院,上海200444 [2]上海大学绍兴研究院,浙江绍兴312000

出　　处：《上海大学学报(自然科学版)》2024年第6期989-1005,共17页Journal of Shanghai University:Natural Science Edition

基　　金：上海市自然科学基金资助项目(20ZR1419600)。

摘　　要：薄膜晶体管(thin-film transistors,TFTs)已广泛应用于生物电子学领域,用来检测代谢物、核酸、蛋白质、细胞活动和电生理信号.在新冠病毒大流行期间,基于TFTs的COVID-19生物传感器展现出良好的性能和高应用潜力.石墨烯场效应晶体管(graphene field-effect transistors,GFETs)、氧化物薄膜晶体管、有机场效应晶体管(organic field-effect transistors,OFETs)和有机电化学晶体管(organic electrochemical transistors,OECTs)等薄膜晶体管在病毒、RNA、抗原、抗体的检测中均取得了良好的结果.总结了基于薄膜晶体管的新冠病毒和相关生物标志物检测的生物传感器,讨论了基于不同沟道材料晶体管的传感策略.最后,对未来薄膜晶体管应用于病毒检测的研究方向提出展望.Thin-film transistors(TFTs)are widely used in bioelectronics for applications in detecting metabolites,nucleic acids,proteins,cellular activities,and electrophysiologi-cal signals.During the COVID-19 pandemic,TFT-based COVID-19 biosensors displayed excellent performances and high levels of potential for use in various applications.TFTs,such as oxide-based TFTs and graphenefield-effect,organicfield-effect,and organic elec-trochemical transistors,yielded promising results in detecting viruses,ribonucleic acid,and antigens and antibodies.This review summarizes biosensors based on TFTs for use in detecting SARS-CoV-2 and the related biomarkers and analyzes sensing strategies based on transistors with different channel materials.Finally,future directions for researches regarding the applications of TFTs in viral detection are proposed.

关 键 词：薄膜晶体管 生物传感器 冠状病毒检测 有机电化学晶体管 有机场效应晶体管 

分 类 号：Q5-3[生物学—生物化学]