cGAS/STING通路及其在针刺改善类风湿性关节炎的神经免疫机制研究新思路  

cGAS/STING Pathway and its Neuroimmune Mechanism in the Improvement of Rheumatoid Arthritis by Acupuncture

作　　者：李媛 徐媛[3] 苑功名 卢圣锋 王宁 LI Yuan;XU Yuan;YUAN Gongming;LU Shengfeng;WANG Ning(College of Acupuncture and Massage,Health and Rehabilitation College,Nanjing University of Chinese Medicine,Nanjing 210023,China;Key Laboratory of Acupuncture and Medicine Research of Ministry of Education,Nanjing University of Chinese Medicine,Nanjing 210023,China;College of Acupuncturemoxibustion and Tuina,Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China)

机构地区：[1]南京中医药大学针灸推拿学院·养生康复学院,南京210023 [2]南京中医药大学教育部针药结合重点实验室,南京2210023 [3]天津中医药大学针灸推拿学院,天津301617

出　　处：《世界科学技术-中医药现代化》2024年第10期2539-2544,共6页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江苏省教育厅面上项目(22KJB360009):STING/IFN信号在针刺调控Nav1.7中的作用及机制研究,负责人:李媛;江苏省自然科学基金青年项目(BK20230453):芳香烃受体AhR介导针刺调节RA肠-关节轴免疫稳态的作用及机制研究,负责人:李媛;江苏省卫健委医学科研项目(Z2023032):针刺通过“AhR-肠道Th17/Treg-关节STING途径”轴调控RA肠-关节轴免疫稳态的作用及机制,负责人:李媛。

摘　　要：针灸常用于类风湿性关节炎(Rheumatoid arthritis,RA)的临床治疗。但其作用机制不清。DNA传感通过环磷酸鸟苷-腺苷合酶(Cyclic GMP-AMP synthase,cGAS)/干扰素基因刺激因子(Stimulator of interferon genes,STING)途径激活先天免疫,诱导炎症反应。同时,STING介导的Ⅰ型干扰素(Type-Ⅰinterferons,IFNs-Ⅰ)信号被证明是伤害性感受的关键调控分子,成为RA干预的潜在靶点。本文回顾了cGAS/STING激活和信号转导的分子机制和功能,特别强调了这一信号通路在周围神经系统神经免疫交互中的抗伤害性作用,并设想了针刺改善RA的神经免疫机制研究的新思路,为针刺治疗RA等免疫失常相关的自身免疫疾病提供新的研究方向,并为干预STING途径的临床转化提供新的策略和方法。Acupuncture is often used in the clinical treatment of Rheumatoid arthritis(RA).However,its mechanism of action remains unclear.DNA sensing activates innate immunity and induces inflammatory responses through the cyclic GMP-AMP synthase(cGAS)/stimulator of interferon genes(STING)pathway.Meanwhile,STING mediated type-Ⅰ interferons(IFNs-Ⅰ)signaling has been proved to be a key regulatory molecule of nociception,which has become a potential target for RAtreatment.This article reviews the molecular mechanisms and functions of cGAS/STING activation and signal transduction,with particular emphasis on the antinociception effect of this signaling pathway in neuroimmune interactions in the peripheral nervous system,and envisage new ideas for the study of the neuroimmune mechanism of acupuncture in improving RA,which provides a new research direction for the treatment of RA and other autoimmune diseases related to immune disorders.It also provides new strategies and methods for the clinical transformation of intervention STING pathway.

关 键 词：针刺 类风湿性关节炎 cGAS/STING通路 神经免疫机制 研究思路 

分 类 号：R245.31[医药卫生—针灸推拿学]