基于肠道菌群-短链脂肪酸-肠PPARγ介导肠上皮代谢探讨针灸修复IBS肠黏膜屏障损伤的可行性  

Based on Microbiota-SCFA-Intestinal PPAR Mediated the Intestinal Epithelial Metabolism to Explore the Feasibility of Acupuncture in Repairing the Intestinal Mucosal Barrier Injury in IBS

作　　者：宋亚芳 蒋诗媛 庄艺 王宇航 孙建华[2] SONG Yafang;JIANG Shiyuan;ZHUANG Yi;WANG Yuhang;SUN Jianhua(School of Acupuncture-Moxibustion and Tuina,School of Health Preservation and Rehabilitation of Nanjing University of Chinese,Nanjing 210023,China;Nanjing University of Chinese Medicine Afiliated Hospital,Nanjing 210029,China)

机构地区：[1]南京中医药大学针灸推拿学院·养生康复学院,南京210023 [2]南京中医药大学附属医院,南京210029

出　　处：《世界科学技术-中医药现代化》2024年第10期2748-2754,共7页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：江苏省中医药科技发展计划青年人才项目(QN202101):从“EGC-ILC3-IEC单元”探讨电针修复IBS肠黏膜屏障损伤机制,负责人:宋亚芳;南京中医药大学罗林秀教师发展基金项目(LLX202304):PPAR-γ/RXR-α介导肠神经胶质细胞活化参与电针缓解PI-IBS小鼠内脏高敏感机制研究,负责人:宋亚芳;国家自然科学基金委员会面上项目(82274630):GDNF-RET介导电针调节神经-结肠上皮对话缓解PI-IBS模型小鼠内脏高敏感的机制研究,负责人:孙建华。

摘　　要：肠易激综合征(Irritable bowel syndrome,IBS)常伴有肠黏膜屏障受损,目前尚缺乏理想的药物疗法。针灸保护IBS肠黏膜屏障优势明显,疗效确切,但分子生物学机制亟待深入。立足于肠道整体稳态的“菌群-肠上皮对话”研究修复损伤的肠黏膜屏障已经成为本领域研究的热点。据此,本文立足于前沿基础,从肠道菌群-短链脂肪酸-肠PPARγ途径介导肠上皮细胞代谢角度探讨针灸修复IBS肠黏膜屏障损伤可行性,以期诠释针灸修复肠黏膜屏障损伤的科学内涵,使针灸疗法在公共医疗卫生中发挥更大作用,为中医药的现代化提供科学依据。Irritable bowel syndrome(IBS)is accompanied by impaired intestinal mucosal barrier,and there is currently no ideal drug therapy.Acupuncture has obvious advantages in protecting intestinal mucosal barrier of IBS,but the molecular biological mechanism needs to be further studied.Based on the overall intestinal homeostasis in the"floraintestinal epithelial dialogue"study to repair damaged intestinal mucosal barrier has become a hot research in this field.Therefore,based on the frontier basis,this paper discusses the feasibility mechanism of acupuncture in repairing IBS intestinal mucosal barrier injury from the perspective of intestinal flora-short-chain fatty acid-intestinal PPAR pathway-mediated intestinal epithelial cell metabolic reprogramming,in order to interpret the scientific connotation of acupuncture in repairing intestinal mucosal barrier injury,and provide a scientific basis for acupuncture therapy to play a greater role in public health care and for the modernization of traditional Chinese medicine.

关 键 词：针灸 肠易激综合征 肠道菌群-短链脂肪酸-肠PPARγ途径 肠上皮代谢 肠黏膜屏障 

分 类 号：R246[医药卫生—针灸推拿学]