Thyroid dysfunction prevalence in high-risk pregnant women and maternal and neonatal consequences after delivery:A retrospective cohort study  

作　　者：Roghaye Ahangari Abolfazl Mohammadbeigi Sepideh Miraj Keivan Ghassami Azadeh Asgarian 

机构地区：[1]Department of Obstetrics and Gynecology,Faculty of Medicine,Qom University of Medical Sciences,Qom,Iran [2]Department of Epidemiology and Biostatistics,Faculty of Health,Qom University of Medical Sciences,Qom,Iran [3]Department of Neurology,Faculty of Medicine,Arak University of Medical Sciences,Arak,Iran [4]Clinical Research Development Center,Forghani Hospital Qom University of Medical Sciences,Qom,Iran

出　　处：《Journal of Acute Disease》2024年第5期185-192,共8页急性病杂志(英文版)

基　　金：funded financially by the Vice Chancellor for Research and Technology Development at Qom University of Medical Sciences.

摘　　要：Objective:To evaluate thyroid dysfunction prevalence and its consequences in high-risk pregnant women and their children.Methods:In this retrospective cohort study,data from high-risk pregnant women who were referred to a governmental referral hospital in Qom,Iran from March to August 2022 were collected.The thyroid disorders were determined according to the 2017 American Thyroid Association guidelines.The predictors of a mother's hypothyroidism and its fetal and maternal consequences were assessed.Independent t-test,Chi-square test,and logistic regression were used for bivariate and multivariate analysis.Results:293 women were included.The prevalence of hypothyroidism and hyperthyroidism based on the thyroid stimulating hormone classification was 32.5%and 2.0%.The prevalence of subclinical and overt hypothyroidism was 6.1%and 4.1%,and the prevalence of subclinical and overt hyperthyroidism was 2.4%and 1.4%,respectively.Family history of thyroid disorders was the most important predictor of hypothyroidism during pregnancy(OR=2.6,95%CI=1.0-6.6,P=0.002),while preterm delivery(OR=2.2,95%CI=1.3-6.8,P=0.220)and elevated neonate thyroid stimulating hormone(OR=1.2,95%CI=1.1-1.3,P=0.041)were the most important consequence of hypothyroidism.Conclusions:Hypothyroidism is a highly prevalent thyroid disorder in high-risk pregnant women.Thyroid function screening should be performed in all pregnant women to increase the detection of subclinical and overt hypothyroidism during pregnancy.

关 键 词：HYPOTHYROIDISM Thyroid disorder Thyroid dysfunction Thyroid stimulating hormone PREGNANCY 

分 类 号：R58[医药卫生—内分泌]