不同剂量醋酸泼尼松治疗难治性肾病综合征患者的效果  

Effect of different dose of prednisone acetate in the treatment of refractory nephrotic syndrome patients

作　　者：陈玉灵 赵世杰 刘先双 Chen Yuling;Zhao Shijie;Liu Xianshuang(Department of Nephrology,Hebi People’s Hospital,Hebi 458030,China)

机构地区：[1]鹤壁市人民医院肾内科,458030

出　　处：《国际移植与血液净化杂志》2024年第6期3-5,共3页International Journal of Transplantation and Hemopurification

摘　　要：目的探讨不同剂量醋酸泼尼松治疗难治性肾病综合征患者的效果。方法选取鹤壁市人民医院肾内科2021年4月至2023年2月期间收治的122例难治性肾病综合征患者作为研究对象,以抽签法随机分为两组。两组患者均给予他克莫司治疗,对照组61例患者给予常规剂量醋酸泼尼松,观察组61例患者给予小剂量醋酸泼尼松治疗,对比两组患者疗效。结果治疗后,两组患者低密度脂蛋白胆固醇和高密度脂蛋白胆固醇水平比较,差异无统计学意义(P>0.05);治疗后,观察组患者不良反应发生率、肾损伤分子-1、抗双链DNA抗体水平较对照组低(P<0.05)。结论小剂量醋酸泼尼松可更好地改善难治性肾病综合征患者的肾功能,且安全性高。Objective To explore the effect of different doses of prednisone acetate on patients with refractory nephrotic syndrome.Methods A total of 122 patients with refractory nephrotic syndrome in Department of Nephrology,Hebi People’s Hospital from April 2021 to February 2023 were enrolled in this study and randomly divided into two groups by lottery.Both groups were treated with tacrolimus.Sixty-one cases in the control group were treated with conventional dose of prednisone acetate,and 61 cases in the observation group were treated with small dose of prednisone acetate.Results There were no significant differences in the levels of low-density lipoprotein cholesterol and high-density lipoprotein cholesterol between the two groups(P>0.05).After the treatment,the incidence of adverse reactions,renal injury molecule-1 and anti-DS-DNA levels in the observation group were lower than those in the control group(P<0.05).Conclusion Low-dose prednisone acetate is more effective and safe in improving renal function in patients with refractory nephrotic syndrome.

关 键 词：剂量 醋酸泼尼松 难治性肾病综合征 

分 类 号：R69[医药卫生—泌尿科学]