两样本孟德尔随机化分析乳腺癌与骨质疏松症的因果关系  

Causality between breast cancer and osteoporosis:A two-sample Mendelian randomization study

作　　者：牛丁忍 李志翔[1] 杨青 李强 冯晓玲[2] NIU Dingren;LI Zhixiang;YANG Qing;LI Qiang;FENG Xiaoling(Heilongjiang University of Traditional Chinese Medicine,Harbin 150040;The First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国骨质疏松杂志》2025年第1期55-61,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金面上项目(81973894,82174421);黑龙江省自然科学基金重点项目(ZD2021H006)。

摘　　要：目的应用孟德尔随机化(Mendelian randomization,MR)法分析乳腺癌(breast cancer,BC)与骨质疏松症(osteoporosis,OP)之间的因果关联。方法使用公开的全基因组关联研究数据集(GWAS),暴露因素为BC,结局变量为OP,采用逆方差加权法(IVW)、加权中位数法(WME)和MR-Egger回归分析BC与OP的因果关系,其中以IVW为主要分析方法。并采用异质性检验、多效性检验及敏感性分析评估研究结果是否稳健。结果IVW分析结果表明BC可能是OP的危险因素(OR=1.09,95%CI:1.03~1.16,P<0.05)。此外,异质性检验、多效性检验及敏感性分析未观察到水平多效性和异质性,表明研究结果稳健可靠。结论BC与OP之间可能存在较为显著的潜在因果关系,BC可能会增加OP的发病风险,这为研究OP的生物学机制及其早期防治提供了新线索,也为循证医学研究提供了新方向。Objective To analyze the causal relationship between breast cancer(BC)and osteoporosis(OP)using Mendelian randomization(MR).Methods Using publicly available genome-wide association study datasets(GWAS),with BC as the exposure factor and OP as the outcome,we conducted inverse variance weighting(IVW),weighted median method(WME),and MR-Egger analyses to examine the causal relationship between BC and OP,with IVW as the primary analysis method.Heterogeneity test,pleiotropy test,and sensitivity analyses were used to evaluate the robustness of the study result.Results The IVW analysis indicated that BC might be a risk factor for OP(OR=1.09,95%CI:1.03-1.16,P<0.05).Furthermore,heterogeneity test,pleiotropy test,and sensitivity analyses did not observe any horizontal pleiotropy or heterogeneity,suggesting that the study result were robust and reliable.Conclusion There may be a significant potential causal relationship between BC and OP,since BC possibly increases the risk of developing OP.This provides new clues for studying the biological mechanisms of OP and its early prevention and treatment,as well as a new direction for evidence-based medical research.

关 键 词：孟德尔随机化 乳腺癌 骨质疏松症 流行病学 

分 类 号：R589.5[医药卫生—内分泌] R737.9[医药卫生—内科学] R181.2[医药卫生—临床医学]