己糖激酶2在类风湿关节炎发病机制中的研究进展  

Research progress of hexokinase 2 in the pathogenesis of rheumatoid arthritis

作　　者：雷海桃 王金海[2] 高韵奇 朱虹 张昊 王海东[1] 苏小军[1] 年芳红 吴海娟[1] 杨会军 田雪梅[1] LEI Haitao;WANG Jinhai;GAO Yunqi;ZHU Hong;ZHANG Hao;WANG Haidong;SU Xiaojun;NIAN Fanghong;WU Haijuan;YANG Huijun;TIAN Xuemei(Department of Rheumatology and Orthopedics Center,Gansu Provincial Hospital of TCM,Lanzhou 730050;Department of TCM,the Second Hospital of Lanzhou University,Lanzhou 730030;Clinical College of TCM,Gansu University of TCM,Lanzhou 730000,China)

机构地区：[1]甘肃省中医院风湿骨病中心,甘肃兰州730050 [2]兰州大学第二医院中医科,甘肃兰州730030 [3]甘肃中医药大学中医临床学院,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2025年第1期90-95,共6页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金项目(82260880);王海东甘肃省名中医传承工作室建设基金资助项目(甘卫中医函[2022]50号);甘肃省卫生健康委员会资助项目(GZKP-2022-13);甘肃省针刀医学产学研合作平台建设项目(2022-3-33);兰州市青年科技人才创新专项(2023-QN-12)。

摘　　要：类风湿关节炎(rheumatoid arthritis,RA)是常见的自身免疫性疾病,以滑膜炎症、骨质破坏和血管翳形成为主要病理特征。其中,葡萄糖代谢失常显著促进了RA的致病行为,特别是己糖激酶2(Hexokinase 2,HK2)可以通过介导糖酵解代谢促进炎症反应、抑制细胞凋亡、促进细胞自噬、诱导线粒体氧化应激,并在免疫调节、骨质破坏和适应缺氧中发挥关键作用,故HK2的异常调节可能参与RA发病的分子机制,并可能成为RA治疗极具吸引力的一个选择性代谢靶点。基于此,笔者系统综述了HK2在RA发病机制中的最新文献,以期为RA的发病机制及治疗途径提供新的参考依据。Rheumatoid arthritis(RA)is a common autoimmune disease characterized by synovitis,bone destruction,and pannus formation.Among them,abnormal glucose metabolism significantly promotes the pathogenic behavior of RA.Especially,hexokinase 2(HK2)promotes inflammation,inhibits apoptosis,promotes autophagy,induces mitochondrial oxidative stress by mediating glycolysis metabolism,and plays a key role in immune regulation,bone destruction,and adaptation to hypoxia.Therefore,the abnormal regulation of HK2 may be involved in the molecular mechanism of RA and may become a very attractive alternative metabolic target for RA therapy.Based on this,this paper systematically reviews the latest literature of HK2 in the pathogenesis of RA,in order to provide new reference basis for the pathogenesis and treatment of RA.

关 键 词：己糖激酶2 类风湿关节炎 发病机制 

分 类 号：R593.22[医药卫生—内科学]