缺氧及高压氧对骨代谢的影响机制  

The impact mechanism of hypoxia and hyperbaric oxygen on bone metabolism

作　　者：张鑫[1] 朱换平[2] 李育光 李鑫生 谢潜锋 ZHANG Xin;ZHU Huanping;LI Yuguang;LI Xinsheng;XIE Qianfeng(Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国骨质疏松杂志》2025年第1期96-99,106,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省科技计划项目(21JR1RA050);兰州市科技计划项目(2021-1-88)。

摘　　要：随着人口老龄化的不断加剧,各种原因引起的骨代谢紊乱越来越严重,其中针对骨质疏松的研究日益广泛。缺氧可通过影响炎症、血管以及成骨细胞和破骨细胞之间的骨稳态从而导致骨代谢异常,引发骨质疏松;高压氧可增加胶原沉积,恢复骨祖细胞活性和骨微循环,改善缺血缺氧损伤,延长降解期,提高骨的硬度和柔韧性。笔者意在探讨研究缺氧状态下的骨稳态失衡以及通过高压氧改善缺氧环境来调节骨骼中的代谢紊乱,从另一个角度来解释骨质疏松的发病机制、发展和治疗,从而在高压氧治疗方面取得新的进展和突破,寻找新的治疗骨质疏松的靶点。With the continuous aging of the population,bone metabolism disorders caused by various reasons are becoming more and more serious,among which research on osteoporosis is becoming increasingly widespread.Hypoxia leads to abnormal bone metabolism and osteoporosis by affecting inflammation,blood vessels,and bone balance between osteoblasts and osteoclasts.Hyperbaric oxygen therapy increases collagen deposition,restores osteoprogenitor cell activity and bone microcirculation,relieves ischemic and hypoxic injury,prolongs the degradation period,and improves bone hardness and flexibility.The purpose of this article is to explore the imbalance of bone homeostasis hypoxia conditions and the regulation of metabolic disorders in the bone through the improvement of hypoxic environment through hyperbaric oxygen.It aims to explain the pathogenesis,development,and treatment of osteoporosis from the other perspective,so as to make new progress and breakthroughs in hyperbaric oxygen treatment and to find new targets for treating osteoporosis.

关 键 词：骨质疏松 骨代谢 缺氧 高压氧 

分 类 号：R589.5[医药卫生—内分泌]