环泊酚在老年患者脑动脉瘤栓塞术中的应用效果  

Effect of ciprofol on embolization of cerebral aneurysms in elderly patients

作　　者：刘婧涵 王媛媛 LIU Jing-han;WANG Yuan-yuan(Department of Anesthesiology,The Forth Affiliated Hospital of China Medical University,Shenyang 110032,China)

机构地区：[1]中国医科大学附属第四医院麻醉科,沈阳110032

出　　处：《中国新药杂志》2024年第24期2582-2586,共5页Chinese Journal of New Drugs

基　　金：辽宁省科学技术计划面上资助项目(2023-MS-157)。

摘　　要：目的:观察环泊酚用于老年患者脑动脉瘤栓塞术全麻诱导和维持中的安全性。方法:选取2022年10月—2023年10月期间于中国医科大学附属第四医院麻醉科进行全麻下气管插管脑动脉瘤栓塞术的老年患者,共60例。随机分为丙泊酚组(P组)和环泊酚组(C组),每组30例。分别采用丙泊酚和环泊酚方案诱导麻醉,记录麻醉诱导前(T0)、诱导后1 min(T1)、气管插管(T2)、栓塞(T3)和麻醉苏醒(T4)时间点血流动力学指标,包括平均动脉压(mean arterial pressure, MAP)和心率(heart rate, HR)等,记录诱导时间、苏醒时间以及注射痛等不良反应发生情况。结果:与T0相比,两组患者在T1和T2时间点MAP及HR均下降(P<0.05),但C组指标水平均高于P组(P<0.05)。C组的麻醉诱导时间明显长于P组,差异具有统计学意义(P<0.05)。C组的注射痛发生率和术中低血压发生率均明显低于P组,差异具有统计学意义(P<0.05)。结论:环泊酚可安全用于接受动脉栓塞术老年患者的麻醉诱导与维持,其优势明显,值得临床广泛应用。Objective:To observe the safety of ciprofol in the induction and maintenance of general anesthesia for cerebral aneurysm embolization in elderly patients.Methods:A total of 60 elderly patients who underwent endotracheal intubation cerebral aneurysm embolization under general anesthesia in our hospital from October 2022 to October 2023 were selected and randomly divided into propofol group(P)and ciprofol group(C),with 30 cases in each group.The hemodynamic indexes,including mean arterial pressure(MAP)and heart rate(HR),were recorded before anesthesia induction(TO),at 1 min after induction(T1),tracheal intubation time(T2),embolization time(T3)and anesthesia recovery time(T4).The induction time,recovery time and occurrence of adverse reactions such as injection pain were recorded.Results:The MAP and HR in both groups were decreased at Tl and T2 compared with TO(P<0.05),but those in group C were higher than those in group P(P<0.05).The induction time of group C was significantly longer than that of group P(P<0.05).The incidence of injection pain and intraoperative hypotension in group C was significantly lower than that in group P(P<0.05).Conclusion:Ciprofol can be safely used in the induction and maintenance of anesthesia in elderly patients undergoing arterial embolization,which has obvious advantages and is worthy of clinical application.

关 键 词：环泊酚 老年患者 脑动脉瘤栓塞术 血流动力学 

分 类 号：R979.1[医药卫生—药品]