盐都区利福平耐药肺结核患者临床特征及治疗转归分析  

Analysis of clinical characteristics and treatment outcome of rifampicin-resistance pulmonary tuberculosis patients in Yandu district

作　　者：李鹏鹏[1] 何飞[1] 袁中行 商明群 江艳 竺丽梅[3] LI Pengpeng;HE Fei;YUAN Zhonghang;SHANG Mingqun;JIANG Yan;ZHU Limei(Yandu District Center for Disease Control and Prevention,Yancheng 224011;the Seventh People's Hospital of Yancheng,Yancheng 224050;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]盐城市盐都区疾病预防控制中心,江苏盐城224011 [2]盐城市第七人民医院,江苏盐城224050 [3]江苏省疾病预防控制中心,江苏南京210009

出　　处：《临床医学研究与实践》2025年第2期13-16,共4页Clinical Research and Practice

基　　金：江苏省卫生健康委科研项目(No.ZDA2020022)。

摘　　要：目的分析盐都区利福平耐药肺结核(RR-PTB)患者临床特征及治疗情况。方法收集2012—2021年盐城市盐都区登记确诊的肺结核患者的临床资料,分析肺结核患者耐药情况、RR-PTB患者的临床特征及治疗转归情况。结果2012—2021年盐都区共发现病原学阳性肺结核患者864例,占所有肺结核患者的30.76%(864/2809);2012—2021年盐都区RR-PTB检出率为11.67%(93/797),呈先上升后下降趋势。2012—2016年、<60岁、高危人群的耐药肺结核(DR-PTB)、RR-PTB和耐多药肺结核(MDR-PTB)检出率均高于2017—2021年、≥60岁、非高危人群(P<0.05)。2012—2021年盐都区共67例RR-PTB患者纳入治疗,成功治疗率为71.64%(48/67)。2017—2021年、<60岁、非高危人群、6个月末痰培养阴性患者的成功治疗率较高,诊断天数≥30 d、合并糖尿病、合并空洞病灶、中断治疗≥14 d患者的成功治疗率较低,差异具有统计学意义(P<0.05)。结论盐都区RR-PTB的防治工作取得了显著成效,但应重点关注≥60岁、高危人群、合并糖尿病、合并空洞病灶等RR-PTB患者的治疗管理,制定针对性的综合防控措施,提高成功治疗率。Objective To analyze the clinical characteristics and treatment outcome of rifampicin-resistance pulmonary tuberculosis(RR-PTB)patients in Yandu district.Methods The clinical data of pulmonary tuberculosis patients registered and diagnosed in Yandu district of Yancheng city from 2012 to 2021 were collected,and the drug resistance of pulmonary tuberculosis patients and the clinical characteristics and treatment outcome of RR-PTB patients were analyzed.Results From 2012 to 2021,a total of 864 patients with pathogenic positive pulmonary tuberculosis were found in Yandu district,accounting for 30.76%(864/2809)of all pulmonary tuberculosis patients;the detection rate of RR-PTB in Yandu district from 2012 to 2021 was 11.67%(93/797),showing a trend of increasing first and then decreasing.The detection rates of drug-resistant pulmonary tuberculosis(DR-PTB),RR-PTB and multidrug-resistant pulmonary tuberculosis(MDR-PTB)in 2012-2016,<60 years old and high-risk population were higher than those in 2017-2021,≥60 years old and non-high-risk population(P<0.05).From 2012 to 2021,a total of 67 patients with RR-PTB were included in treatment in Yandu district,and the successful treatment rate was 71.64%(48/67).The successful treatment rate of patients admitted from 2017 to 2021,<60 years old,of non-high-risk population and with sputum culture negative category at the end of 6 months were higher,while the successful treatment rate of patients with diagnosis days≥30 days,complicated with diabetes mellitus,combined with cavity lesions and interruption of treatment≥14 days were lower,and the differences were statistically significant(P<0.05).Conclusion The prevention and treatment of RR-PTB in Yandu district has achieved remarkable results.It should be focused on the treatment and management of RR-PTB patients aged≥60 years,high-risk population,patients complicated with diabetes and cavity lesions,and targeted comprehensive prevention and control measures should be formulated to improve the success rate of treatment.

关 键 词：利福平耐药肺结核 临床特征 治疗转归 

分 类 号：R521[医药卫生—内科学]